Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain (Q40736227)

23 September 2017

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain (English)

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23 September 2017

Hitoshi Kiyoi

1

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23 September 2017

Ryuzo Ohno

2

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23 September 2017

Ryuzo Ueda

3

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23 September 2017

Hidehiko Saito

4

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23 September 2017

Tomoki Naoe

5

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23 September 2017

language of work or name

English

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publication date

1 April 2002

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23 September 2017

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23 September 2017

21

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23 September 2017

2555-2563

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23 September 2017

16

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205332

23 September 2017

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cites work

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Intramolecular interactions between the juxtamembrane domain and phosphatase domains of receptor protein-tyrosine phosphatase RPTPmu. Regulation of catalytic activity

21 January 2018

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Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

21 January 2018

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SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain

21 January 2018

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Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region.

21 January 2018

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SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor

21 January 2018

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A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

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Molecular chaperones: the busy life of Hsp90.

21 January 2018

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Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia

21 January 2018

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Role of c-kit receptor tyrosine kinase in the development, survival and neoplastic transformation of mast cells

21 January 2018

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Switching signals on or off by receptor dimerization

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Hsp90 chaperones protein folding in vitro.

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Insights into Src kinase functions: structural comparisons

21 January 2018

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Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

21 January 2018

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Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

21 January 2018

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In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

21 January 2018

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c-Kit and c-kit mutations in mastocytosis and other hematological diseases.

21 January 2018

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7 January 2021

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding

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7 January 2021

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

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7 January 2021

Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia

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7 January 2021

Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan

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7 January 2021

Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho)

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7 January 2021

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

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7 January 2021

Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia

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7 January 2021

RTK mutations and human syndromes: when good receptors turn bad

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7 January 2021

Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene

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7 January 2021

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205332

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205332

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Dimensions Publication ID

23 September 2017

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