Current Concepts and Controversies in Innate Immunity of Cystic Fibrosis Lung Disease. (Q40473713)

20 September 2017

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title

Current Concepts and Controversies in Innate Immunity of Cystic Fibrosis Lung Disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6738757&resulttype=core&format=json

12 May 2020

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3

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12 May 2020

author name string

Anjali Ralhan

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6738757&resulttype=core&format=json

12 May 2020

Julie Laval

2

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12 May 2020

Marlene Ballbach

4

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12 May 2020

Charlotte Grund

5

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12 May 2020

Andreas Hector

6

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12 May 2020

Dominik Hartl

7

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12 May 2020

publication date

1 July 2016

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Journal of Innate Immunity

20 September 2017

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12 May 2020

volume

8

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12 May 2020

issue

6

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12 May 2020

page(s)

531-540

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Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis

12 May 2020

cites work

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12 December 2020

Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa

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12 December 2020

TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis

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12 December 2020

A Toll-like receptor recognizes bacterial DNA

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12 December 2020

Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis

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12 December 2020

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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12 December 2020

Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1.

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12 December 2020

IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2.

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12 December 2020

Human Toll-like receptor 4 recognizes host-specific LPS modifications.

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12 December 2020

Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers

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12 December 2020

Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus

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12 December 2020

Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages

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12 December 2020

Noninvasive biomarkers of airway inflammation in cystic fibrosis

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12 December 2020

Pseudomonas aeruginosa Flagella Activate Airway Epithelial Cells through asialoGM1 and Toll-Like Receptor 2 as well as Toll-Like Receptor 5

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12 December 2020

Toll-like receptors in normal and cystic fibrosis airway epithelial cells.

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12 December 2020

Cystic fibrosis airway epithelial cell polarity and bacterial flagellin determine host response to Pseudomonas aeruginosa

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12 December 2020

Pseudomonas aeruginosa lipid A diversity and its recognition by Toll-like receptor 4.

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12 December 2020

The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo.

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12 December 2020

Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4.

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12 December 2020

Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2

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12 December 2020

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

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12 December 2020

Different domains of Pseudomonas aeruginosa exoenzyme S activate distinct TLRs

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12 December 2020

The endocannabinoid system and its therapeutic exploitation

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12 December 2020

Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition

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12 December 2020

TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells.

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12 December 2020

Toll-like receptors as key mediators in innate antifungal immunity

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12 December 2020

NOD-LRR proteins: role in host-microbial interactions and inflammatory disease

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12 December 2020

Genetic modifiers of lung disease in cystic fibrosis

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12 December 2020

Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5.

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12 December 2020

Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF-alpha, and IL-1beta.

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12 December 2020

Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display

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12 December 2020

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

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12 December 2020

The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus

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12 December 2020

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

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12 December 2020

Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

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12 December 2020

Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis

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12 December 2020

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

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12 December 2020

Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria

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12 December 2020

Polymorphisms of TGF-beta1 in cystic fibrosis patients

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12 December 2020

Nod-like proteins in immunity, inflammation and disease

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12 December 2020

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation

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12 December 2020

Association between pulmonary function and sputum biomarkers in cystic fibrosis

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12 December 2020

Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells

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12 December 2020

The role of flagellin versus motility in acute lung disease caused by Pseudomonas aeruginosa.

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12 December 2020

Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages

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12 December 2020

Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis

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12 December 2020

Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10

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12 December 2020

Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease

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12 December 2020

Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.

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12 December 2020

TNF-alpha induction by Pseudomonas aeruginosa lipopolysaccharide or slime-glycolipoprotein in human monocytes is regulated at the level of Mitogen-activated Protein Kinase activity: a distinct role of Toll-like receptor 2 and 4

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12 December 2020

Anti-inflammatory therapies for cystic fibrosis-related lung disease

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12 December 2020

Modulation of cystic fibrosis lung disease by variants in interleukin-8.

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12 December 2020

Immunological mechanisms behind the cystic fibrosis-ABPA link

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12 December 2020

TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease

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12 December 2020

Inhibition of airway proteases in cystic fibrosis lung disease

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12 December 2020

Update on gene modifiers in cystic fibrosis

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12 December 2020

Ibuprofen therapy for cystic fibrosis lung disease: revisited

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12 December 2020

Occurrence and relevance of filamentous fungi in respiratory secretions of patients with cystic fibrosis--a review

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12 December 2020

Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms.

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12 December 2020

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

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12 December 2020

Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs

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12 December 2020

Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa.

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12 December 2020

Innate immune receptors on neutrophils and their role in chronic lung disease

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12 December 2020

TLR-4-mediated innate immunity is reduced in cystic fibrosis airway cells.

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12 December 2020

The innate immune response to Aspergillus fumigatus

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12 December 2020

Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells

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12 December 2020

EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity

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12 December 2020

Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis.

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12 December 2020

Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome

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12 December 2020

Proline-Glycine-Proline (PGP) and High Mobility Group Box Protein-1 (HMGB1): Potential Mediators of Cystic Fibrosis Airway Inflammation

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12 December 2020

Pseudomonas aeruginosa evasion of phagocytosis is mediated by loss of swimming motility and is independent of flagellum expression

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12 December 2020

Innate antifungal immunity: the key role of phagocytes

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12 December 2020

TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis

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12 December 2020

Modifier genes in Mendelian disorders: the example of cystic fibrosis

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12 December 2020

Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice.

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12 December 2020

Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis.

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12 December 2020

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

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12 December 2020

Initial interrogation, confirmation and fine mapping of modifying genes: STAT3, IL1B and IFNGR1 determine cystic fibrosis disease manifestation

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12 December 2020

Current concepts of hyperinflammation in chronic granulomatous disease

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12 December 2020

Cystic fibrosis transmembrane conductance regulator regulates epithelial cell response to Aspergillus and resultant pulmonary inflammation

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12 December 2020

Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88.

1 reference

12 December 2020

Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing.

1 reference

12 December 2020

Synergism between interleukin (IL)-17 and Toll-like receptor 2 and 4 signals to induce IL-8 expression in cystic fibrosis airway epithelial cells.

1 reference

12 December 2020

The airway microbiota in cystic fibrosis: a complex fungal and bacterial community--implications for therapeutic management

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12 December 2020

Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells

1 reference

12 December 2020

Effect of azithromycin on systemic markers of inflammation in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa.

1 reference

12 December 2020

Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis

1 reference

12 December 2020

Toll-like receptors in the host defense against Pseudomonas aeruginosa respiratory infection and cystic fibrosis

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12 December 2020

Innate immunity in cystic fibrosis lung disease

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12 December 2020

Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation

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12 December 2020

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

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12 December 2020

Expression and regulation of interferon-related development regulator-1 in cystic fibrosis neutrophils

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12 December 2020

Direct interaction studies between Aspergillus fumigatus and human immune cells; what have we learned about pathogenicity and host immunity?

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12 December 2020

Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells

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12 December 2020

NET balancing: a problem in inflammatory lung diseases

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12 December 2020

Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus

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12 December 2020

The cystic fibrosis airway microbiome

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12 December 2020

Proteolytic cleavage of the long pentraxin PTX3 in the airways of cystic fibrosis patients

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12 December 2020

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

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12 December 2020

Molecular mechanisms regulating NETosis in infection and disease

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12 December 2020

Aspergillus-associated airway disease, inflammation, and the innate immune response

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12 December 2020

Genetic variations in toll-like receptor pathway and lung function decline in Cystic fibrosis patients.

1 reference

12 December 2020

Fungal infections and treatment in cystic fibrosis

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12 December 2020

Resolution of acute inflammation in the lung

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12 December 2020

The cystic fibrosis lung microbiome

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12 December 2020

Pseudomonas aeruginosa type-3 secretion system dampens host defense by exploiting the NLRC4-coupled inflammasome.

1 reference

12 December 2020

Lung disease modifier genes in cystic fibrosis.

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12 December 2020

Toll-like receptor 9 deficiency protects mice against Pseudomonas aeruginosa lung infection

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12 December 2020

Fungi in the cystic fibrosis lung: bystanders or pathogens?

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12 December 2020

Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes

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12 December 2020

Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lung infection

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12 December 2020

Emerging cystic fibrosis pathogens and the microbiome

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12 December 2020

Cystic fibrosis sputum DNA has NETosis characteristics and neutrophil extracellular trap release is regulated by macrophage migration-inhibitory factor

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12 December 2020

CFTR: cystic fibrosis and beyond

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12 December 2020

Regulation of the inflammasome by ceramide in cystic fibrosis lungs.

1 reference

12 December 2020

Emerging Concepts about NAIP/NLRC4 Inflammasomes

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12 December 2020

Current concepts: host-pathogen interactions in cystic fibrosis airways disease

1 reference

12 December 2020

Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.

1 reference

12 December 2020

The role of airway epithelial cells and innate immune cells in chronic respiratory disease

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12 December 2020

Pattern recognition receptors in antifungal immunity

1 reference

12 December 2020

Pharmacokinetics and tolerability of oral sildenafil in adults with cystic fibrosis lung disease

1 reference

12 December 2020

The NAIP/NLRC4 inflammasomes

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12 December 2020

Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis.

1 reference

12 December 2020

The innate immune function of airway epithelial cells in inflammatory lung disease

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12 December 2020

Neutrophils: Between host defence, immune modulation, and tissue injury

1 reference

12 December 2020

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy

1 reference

12 December 2020

Use of ibuprofen to assess inflammatory biomarkers in induced sputum: Implications for clinical trials in cystic fibrosis

1 reference

12 December 2020

The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus

1 reference

12 December 2020

Activation of NLRC4 downregulates TLR5-mediated antibody immune responses against flagellin

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12 December 2020

Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction

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12 December 2020

The innate immune response to Aspergillus fumigatus at the alveolar surface.

1 reference

12 December 2020

H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses.

1 reference

12 December 2020

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia

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12 December 2020

Staphylococcus aureus Inhibits IL-8 Responses Induced by Pseudomonas aeruginosa in Airway Epithelial Cells.

1 reference

12 December 2020

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

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12 December 2020

Approaching the asymptote? Evolution and revolution in immunology

1 reference

12 December 2020

Alpha-1 Antitrypsin Therapy in Cystic Fibrosis and the Lung Disease Associated with Alpha-1 Antitrypsin Deficiency.

1 reference

12 December 2020

Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group

1 reference

12 December 2020

Effect of high-dose ibuprofen in patients with cystic fibrosis.

1 reference

12 December 2020

Asialo GM1 is a receptor for Pseudomonas aeruginosa adherence to regenerating respiratory epithelial cells

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12 December 2020

Binding and germination of Aspergillus fumigatus conidia on cultured A549 pneumocytes.

1 reference

12 December 2020

Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung.

1 reference

12 December 2020

Salmonella typhi uses CFTR to enter intestinal epithelial cells.

1 reference

12 December 2020

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