Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. (Q35034255)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593379%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis (English)

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1 February 2020

0 references

0 references

3

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1 February 2020

5

Ruslan Medzhitov

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1 February 2020

Emanuela M Bruscia

1

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1 February 2020

Ping-Xia Zhang

2

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1 February 2020

Christina Caputo

4

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1 February 2020

Ambika Shenoy

6

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1 February 2020

Marie E Egan

7

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1 February 2020

Diane S Krause

8

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1 February 2020

language of work or name

English

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publication date

18 May 2011

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1 February 2020

published in

Journal of Immunology

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1 February 2020

volume

186

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1 February 2020

page(s)

6990-6998

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1 February 2020

issue

12

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Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses

1 February 2020

cites work

1 reference

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Proinflammatory phenotype and increased caveolin-1 in alveolar macrophages with silenced CFTR mRNA

8 July 2018

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Localisation and trafficking of Toll-like receptors: an important mode of regulation.

8 July 2018

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Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages

8 July 2018

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TLR-4-mediated innate immunity is reduced in cystic fibrosis airway cells.

8 July 2018

1 reference

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Revisiting the role of cystic fibrosis transmembrane conductance regulator and counterion permeability in the pH regulation of endocytic organelles

8 July 2018

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TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway

8 July 2018

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Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells

8 July 2018

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Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis

8 July 2018

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Chaperones and transport proteins regulate TLR4 trafficking and activation

8 July 2018

1 reference

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CFTR is a negative regulator of NFkappaB mediated innate immune response

8 July 2018

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Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis

8 July 2018

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Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis

8 July 2018

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Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

8 July 2018

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

8 July 2018

1 reference

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Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages

8 July 2018

1 reference

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Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages

8 July 2018

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Cellular image analysis and imaging by flow cytometry

8 July 2018

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Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4

8 July 2018

1 reference

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Misassembled mutant DeltaF508 CFTR in the distal secretory pathway alters cellular lipid trafficking

8 July 2018

1 reference

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CFTR Expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis

8 July 2018

1 reference

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CFTR inhibition mimics the cystic fibrosis inflammatory profile

8 July 2018

1 reference

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Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering

8 July 2018

1 reference

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Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

8 July 2018

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Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation

8 July 2018

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Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered

8 July 2018

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The biogenesis of multivesicular endosomes

8 July 2018

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State of the Art: Why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection?

8 July 2018

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Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction

8 July 2018

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8 July 2018

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Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartment

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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25 October 2018

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Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice

25 October 2018

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Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activat

25 October 2018

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Reduced iC3b-mediated phagocytotic capacity of pulmonary neutrophils in cystic fibrosis

25 October 2018

1 reference

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Dysregulation of IL-2 and IL-8 production in circulating T lymphocytes from young cystic fibrosis patients

25 October 2018

1 reference

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Toll-like receptors in normal and cystic fibrosis airway epithelial cells.

25 October 2018

1 reference

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Overexpression of Toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice.

25 October 2018

1 reference

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Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation

25 October 2018

1 reference

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Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4

25 October 2018

1 reference

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Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-kappa B

9 December 2018

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12 December 2020

Toll like receptor family (TLT) and signalling pathway

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12 December 2020

Regulation of Toll-like receptors in human monocytes and dendritic cells

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12 December 2020

Distinct pattern of immune cell population in the lung of human fetuses with cystic fibrosis

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12 December 2020

Early pulmonary inflammation in infants with cystic fibrosis

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12 December 2020

CFTR regulates phagosome acidification in macrophages and alters bactericidal activity

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12 December 2020

Cytokine dysregulation in activated cystic fibrosis (CF) peripheral lymphocytes

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12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1100396

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593379%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

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1 February 2020

1 reference