Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. (Q40447332)

20 September 2017

Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. (English)

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Peter Henry St George-Hyslop

20 September 2017

object named as

Peter St George-Hyslop

15

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Bart De Strooper

9

object named as

Bart De Strooper

1 reference

20 September 2017

Yoshifumi Nakaya

1

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20 September 2017

Takuya Yamane

2

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20 September 2017

Hirohisa Shiraishi

3

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20 September 2017

Hua-Qin Wang

4

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20 September 2017

Etsuro Matsubara

5

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20 September 2017

Toru Sato

6

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20 September 2017

Georgia Dolios

7

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20 September 2017

Rong Wang

8

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20 September 2017

Mikio Shoji

10

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20 September 2017

Hiroto Komano

11

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20 September 2017

Katsuhiko Yanagisawa

12

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20 September 2017

Yasuo Ihara

13

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20 September 2017

Paul Fraser

14

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20 September 2017

Masaki Nishimura

16

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20 September 2017

language of work or name

English

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publication date

10 March 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

19

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20 September 2017

19070-19077

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Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

20 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

The Role of presenilins in gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Efficient screening of retroviral cDNA expression libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

A new functional screening system for identification of regulators for the generation of amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

A presenilin 1 R278I mutation presenting with language impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501130200

21 January 2018

Identifiers

DOI

10.1074/JBC.M501130200

1 reference

20 September 2017

1 reference