Genetic knockouts in mice: an update (Q40382136)

20 September 2017

1 reference

title

Genetic knockouts in mice: an update (English)

1 reference

20 September 2017

B S Shastry

1

1 reference

20 September 2017

1 November 1995

1 reference

20 September 2017

1 reference

20 September 2017

51

1 reference

20 September 2017

11

1 reference

20 September 2017

1028-1039

1 reference

Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy

20 September 2017

1 reference

https://api.crossref.org/works/10.1007%2FBF01946911

A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01946911

Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01946911

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01946911

Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS.

21 January 2018

1 reference

12 December 2020

Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles

1 reference

12 December 2020

Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development

1 reference

12 December 2020

Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene

1 reference

12 December 2020

Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development

1 reference

12 December 2020

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.

1 reference

12 December 2020

An HMG-box-containing T-cell factor required for thymocyte differentiation.

1 reference

12 December 2020

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1 reference

12 December 2020

Negative feedback regulation of IgE synthesis by murine CD23.

1 reference

12 December 2020

Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses

1 reference

12 December 2020

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

12 December 2020

Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker

1 reference

12 December 2020

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

1 reference

12 December 2020

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

1 reference

12 December 2020

Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia

1 reference

12 December 2020

Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes

1 reference

12 December 2020

Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

1 reference

12 December 2020

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

1 reference

12 December 2020

Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly

1 reference

12 December 2020

MARCKS deficiency in mice leads to abnormal brain development and perinatal death

1 reference

12 December 2020

Cardiac malformation in neonatal mice lacking connexin43.

1 reference

12 December 2020

An early haematopoietic defect in mice lacking the transcription factor GATA-2

1 reference

12 December 2020

Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease

1 reference

12 December 2020

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1 reference

12 December 2020

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1 reference

12 December 2020

The role of Rab3A in neurotransmitter release.

1 reference

12 December 2020

Immune function in mice lacking the perforin gene

1 reference

12 December 2020

Physiological consequences of loss of plasminogen activator gene function in mice

1 reference

12 December 2020

Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells

1 reference

12 December 2020

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1 reference

12 December 2020

Normal long bone growth and development in type X collagen-null mice

1 reference

12 December 2020

Double targeted gene replacement for creating null mutants

1 reference

12 December 2020

Recent experiments with MHC knock-out mice: more questions than answers

1 reference

12 December 2020

Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions

1 reference

12 December 2020

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development

1 reference

12 December 2020

Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.

1 reference

12 December 2020

Gene targeting and synaptic plasticity

1 reference

12 December 2020

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

1 reference

12 December 2020

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

1 reference

12 December 2020

Scatter factor/hepatocyte growth factor is essential for liver development

1 reference

12 December 2020

Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation

1 reference

12 December 2020

Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin beta 2

1 reference

12 December 2020

Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology

1 reference

12 December 2020

Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system

1 reference

12 December 2020

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1 reference

12 December 2020

The murine N-ras gene is not essential for growth and development

1 reference

12 December 2020

Angiotensinogen-deficient mice with hypotension

1 reference

12 December 2020

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1 reference

12 December 2020

Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons

1 reference

12 December 2020

Altering the genome by homologous recombination

1 reference

12 December 2020

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation

1 reference

12 December 2020

Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice

1 reference

12 December 2020

Manipulation of transgenes by site-specific recombination: use of Cre recombinase

1 reference

12 December 2020

Targeted gene replacement.

1 reference

12 December 2020

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

1 reference

12 December 2020

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1 reference

12 December 2020

Mice lacking vimentin develop and reproduce without an obvious phenotype

1 reference

12 December 2020

Two different subunits associate to create isoform-specific platelet-derived growth factor receptors

1 reference

12 December 2020

Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus

1 reference

12 December 2020

Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension

1 reference

12 December 2020

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

1 reference

12 December 2020

The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo

1 reference

12 December 2020

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum

1 reference

12 December 2020

Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene.

1 reference

12 December 2020

Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions

1 reference

12 December 2020

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

1 reference

12 December 2020

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

1 reference

12 December 2020

Essential role of Mash-2 in extraembryonic development

1 reference

12 December 2020

Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs

1 reference

12 December 2020

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

12 December 2020

MyoD or Myf-5 is required for the formation of skeletal muscle

1 reference

12 December 2020

Degeneration of neural cells in the central nervous system of mice deficient in the gene for the adhesion molecule on Glia, the beta 2 subunit of murine Na,K-ATPase

1 reference

12 December 2020

Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice

1 reference

12 December 2020

Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia

1 reference

12 December 2020

Altering mice by homologous recombination using embryonic stem cells

1 reference

12 December 2020

Creation and phenotypic analysis of alpha-lactalbumin-deficient mice

1 reference

12 December 2020

E-cadherin null mutant embryos fail to form a trophectoderm epithelium

1 reference

12 December 2020

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

1 reference

12 December 2020

Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43

1 reference

12 December 2020

Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium

1 reference

12 December 2020

Altered inflammatory responses in leukotriene-deficient mice

1 reference

12 December 2020

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

1 reference

12 December 2020

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

1 reference

12 December 2020

Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice

1 reference

12 December 2020

Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A.

1 reference

12 December 2020

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

1 reference

12 December 2020

Redundancies, development and the flow of information

1 reference

12 December 2020

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion

1 reference

12 December 2020

The helix-loop-helix gene E2A is required for B cell formation

1 reference

12 December 2020

Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins

1 reference

12 December 2020

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

1 reference

12 December 2020

Milk composition and lactation of beta-casein-deficient mice.

1 reference

12 December 2020

Altered striatal function in a mutant mouse lacking D1A dopamine receptors

1 reference

12 December 2020

Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal.

1 reference

12 December 2020

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

12 December 2020

Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization

1 reference

12 December 2020

Murine FGFR-1 is required for early postimplantation growth and axial organization

1 reference

12 December 2020

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.

1 reference

12 December 2020

1 reference

12 December 2020

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

1 reference

12 December 2020

Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene

1 reference

12 December 2020

Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis

1 reference

12 December 2020

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family

1 reference

12 December 2020

Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.

1 reference

12 December 2020

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice

1 reference

12 December 2020

Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease

1 reference

12 December 2020

Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1

1 reference

12 December 2020

Parthenogenetic activation of oocytes in c-mos-deficient mice

1 reference

12 December 2020

Thinking about genetic redundancy

1 reference

12 December 2020

Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice

1 reference

12 December 2020

Animal models of human genetic diseases

1 reference

12 December 2020

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs

1 reference

12 December 2020

Hematopoietic development of vav-/- mouse embryonic stem cells

1 reference

12 December 2020

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

12 December 2020

Requirement for Lim1 in head-organizer function

1 reference

12 December 2020

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells

1 reference

12 December 2020

HNF-3 beta is essential for node and notochord formation in mouse development

1 reference

12 December 2020

Requirement of FGF-4 for postimplantation mouse development

1 reference

12 December 2020

Active anaphylaxis in IgE-deficient mice

1 reference

12 December 2020

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

1 reference

12 December 2020

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages

1 reference

12 December 2020

Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants

1 reference

12 December 2020

Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice

1 reference

12 December 2020

Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice

1 reference

12 December 2020

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1 reference

12 December 2020

Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors

1 reference

12 December 2020

Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells

1 reference

12 December 2020

Impaired immune and acute-phase responses in interleukin-6-deficient mice.

1 reference

12 December 2020

Noradrenaline is essential for mouse fetal development

1 reference

12 December 2020

Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice

1 reference

12 December 2020

Gene disruption in mammals

1 reference

12 December 2020

Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene

1 reference

12 December 2020

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities

1 reference

12 December 2020

P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli

1 reference

12 December 2020

MHC class I expression in mice lacking the proteasome subunit LMP-7

1 reference

12 December 2020

Homeotic transformation of cervical vertebrae in Hoxa-4 mutant mice

1 reference

12 December 2020

Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand

1 reference

12 December 2020

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit

1 reference

12 December 2020

Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

1 reference

12 December 2020

Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb

1 reference

12 December 2020

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1 reference

12 December 2020

Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation

1 reference

12 December 2020

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1 reference

12 December 2020

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1 reference

12 December 2020

Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

1 reference

12 December 2020

Thrombocytopenia in c-mpl-deficient mice

1 reference

12 December 2020

Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis.

1 reference

12 December 2020

Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene.

1 reference

12 December 2020

Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.

1 reference

12 December 2020

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

1 reference

12 December 2020

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

1 reference

12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

12 December 2020

Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants.

1 reference

12 December 2020

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity

1 reference

12 December 2020

Insulin-promoter-factor 1 is required for pancreas development in mice

1 reference

12 December 2020

Gene targeting and development of the nervous system

1 reference

12 December 2020

Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes

1 reference

12 December 2020

More to learn from gene knockouts

1 reference

12 December 2020

Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.

1 reference

12 December 2020

Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.

1 reference

12 December 2020

Correction of a human beta S-globin gene by gene targeting

1 reference

12 December 2020

Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both CRABPI and CRABPII are essentially normal

1 reference

12 December 2020

Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need

1 reference

12 December 2020

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1 reference

12 December 2020

The Ikaros gene is required for the development of all lymphoid lineages

1 reference

12 December 2020

Hox11 controls the genesis of the spleen

1 reference

12 December 2020

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF01946911

1 reference

release_6ffxlaivqzfgbnz2qk7kesr2oe

20 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/6ffxlaivqzfgbnz2qk7kesr2oe

24 November 2022

mapped directly with Wikidata item

PubMed ID

7498440

1 reference

PubMed ID

7498440