Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model. (Q40354888)

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29 February 2020

title

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model (English)

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29 February 2020

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2

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29 February 2020

Jérôme Braudeau

3

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29 February 2020

Florian Brod

8

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29 February 2020

Mickael Audrain

9

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29 February 2020

Alexis-Pierre Bemelmans

10

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29 February 2020

13

Nathalie Cartier

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29 February 2020

author name string

Romain Fol

1

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29 February 2020

Susann Ludewig

4

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29 February 2020

Tobias Abel

5

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29 February 2020

Sascha W Weyer

6

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29 February 2020

Jan-Peter Roederer

7

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29 February 2020

Christian J Buchholz

11

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29 February 2020

Martin Korte

12

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29 February 2020

Ulrike C Müller

14

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29 February 2020

publication date

4 November 2015

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29 February 2020

published in

Acta Neuropathologica

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29 February 2020

volume

131

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29 February 2020

issue

2

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29 February 2020

page(s)

247-266

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https://scigraph.springernature.com/pub.10.1007/s00401-015-1498-9

29 February 2020

exact match

0 references

cites work

Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

BACE1 and BACE2 enzymatic activities in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Universal real-time PCR for the detection and quantification of adeno-associated virus serotype 2-derived inverted terminal repeat sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Functions of the APP gene family in the nervous system: insights from mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

ADAM-10 over-expression increases cortical synaptogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Effect of needle insertion speed on tissue injury, stress, and backflow distribution for convection-enhanced delivery in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Secreted amyloid precursor protein-alpha upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

sAPPα rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Neto1 associates with the NMDA receptor/amyloid precursor protein complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

A phase 3 trial of semagacestat for treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Pathology associated with AAV mediated expression of beta amyloid or C100 in adult mouse hippocampus and cerebellum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Regulation of α-secretase ADAM10 expression and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

TREM2 Variants in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

The upside of APP at synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Differential role of APP and APLPs for neuromuscular synaptic morphology and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

The peptide sequence Arg-Glu-Arg, present in the amyloid precursor protein, protects against memory loss caused by A beta and acts as a cognitive enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Aβ-degrading enzymes: potential for treatment of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Neurotrophic and neuroprotective effects of hAPP in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Microglia actions in Alzheimer’s disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Memory retrieval impairment induced by hippocampal CA3 lesions is blocked by adrenocortical suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Alzheimer's disease is a synaptic failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Spines, plasticity, and cognition in Alzheimer's model mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Faithful expression of multiple proteins via 2A-peptide self-processing: a versatile and reliable method for manipulating brain circuits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Upregulation of amyloid precursor protein messenger RNA in response to traumatic brain injury: an ovine head impact model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9

Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1498-9