ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function (Q33926960)

30 July 2017

ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function (English)

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30 July 2017

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7

Rudolph E Tanzi

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5

Andrea N Lesinski

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6

Doo Yeon Kim

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Jaehong Suh

1

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30 July 2017

Se Hoon Choi

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2

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Donna M Romano

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3

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Moira A Gannon

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4

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30 July 2017

language of work or name

English

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publication date

19 September 2013

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80

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2

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385-401

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describes a project that uses

30 July 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4105199/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

28 July 2018

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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

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The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

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Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity

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Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

28 July 2018

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ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase

28 July 2018

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The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.

28 July 2018

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The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

28 July 2018

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ADAM-10 over-expression increases cortical synaptogenesis

28 July 2018

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Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold

28 July 2018

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BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

28 July 2018

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A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

28 July 2018

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Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity

28 July 2018

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The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

28 July 2018

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Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.

28 July 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

28 July 2018

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28 July 2018

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28 July 2018

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

28 July 2018

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Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

28 July 2018

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28 July 2018

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29 October 2018

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The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer.

29 October 2018

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29 October 2018

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Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

29 October 2018

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Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

29 October 2018

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Alpha-secretase activation--an approach to Alzheimer's disease therapy

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105199

Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

29 October 2018

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In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

29 October 2018

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Intracellular processing of metalloprotease disintegrin ADAM12.

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105199

ADAM13 disintegrin and cysteine-rich domains bind to the second heparin-binding domain of fibronectin

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105199

Protein memory through altered folding mediated by intramolecular chaperones.

29 October 2018

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105199

The propeptide domain of membrane type 1-matrix metalloproteinase acts as an intramolecular chaperone when expressed in trans with the mature sequence in COS-1 cells

29 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24055016

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEURON.2013.08.035

1 reference

30 July 2017

1 reference

30 July 2017

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