Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production. (Q46055931)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

author name string

Sarah E Hoey

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Michael S Perkinton

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

language of work or name

English

0 references

publication date

1 April 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

volume

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

page(s)

4442-4460

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

issue

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

25 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6665739/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

12 December 2020

Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons

1 reference

12 December 2020

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

1 reference

12 December 2020

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

1 reference

12 December 2020

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

1 reference

12 December 2020

The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.

1 reference

12 December 2020

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

12 December 2020

Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene

1 reference

12 December 2020

A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication

1 reference

12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

12 December 2020

Neuronal protein kinase signaling cascades and excitotoxic cell death

1 reference

12 December 2020

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme

1 reference

12 December 2020

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

12 December 2020

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

12 December 2020

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

1 reference

12 December 2020

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

1 reference

12 December 2020

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

1 reference

12 December 2020

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

1 reference

12 December 2020

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

1 reference

12 December 2020

Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones.

1 reference

12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

12 December 2020

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

1 reference

12 December 2020

Alzheimer's disease is a synaptic failure

1 reference

12 December 2020

The Yin and Yang of NMDA receptor signalling

1 reference

12 December 2020

Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway.

1 reference

12 December 2020

APP processing and synaptic function

1 reference

12 December 2020

Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons

1 reference

12 December 2020

The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo

1 reference

12 December 2020

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

12 December 2020

The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling

1 reference

12 December 2020

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

1 reference

12 December 2020

Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

1 reference

12 December 2020

Amyloid-beta precursor protein processing in neurodegeneration

1 reference

12 December 2020

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

1 reference

12 December 2020

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

1 reference

12 December 2020

Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.

1 reference

12 December 2020

Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

12 December 2020

Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory

1 reference

12 December 2020

NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production.

1 reference

12 December 2020

Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

1 reference

12 December 2020

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

1 reference

12 December 2020

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

1 reference

12 December 2020

Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons

1 reference

12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

12 December 2020

The gamma-secretase complex: membrane-embedded proteolytic ensemble

1 reference

12 December 2020

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

1 reference

12 December 2020

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

12 December 2020

A beta oligomers - a decade of discovery

1 reference

12 December 2020

Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.

1 reference

12 December 2020

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

1 reference

12 December 2020

beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment

1 reference

12 December 2020

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

12 December 2020

Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.

1 reference

12 December 2020

An AICD-based functional screen to identify APP metabolism regulators.

1 reference

12 December 2020

Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.

1 reference

12 December 2020

Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells

1 reference

12 December 2020

Amyloid flirting with synaptic failure: towards a comprehensive view of Alzheimer's disease pathogenesis.

1 reference

12 December 2020

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

1 reference

12 December 2020

Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories

1 reference

12 December 2020

The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway

1 reference

12 December 2020

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

1 reference

12 December 2020

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

1 reference

12 December 2020

Visualizing hippocampal synaptic function by optical detection of Ca2+ entry through the N-methyl-D-aspartate channel

1 reference

12 December 2020

Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats.

1 reference

12 December 2020

Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein

1 reference

12 December 2020

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

1 reference

12 December 2020

A synaptic model of memory: long-term potentiation in the hippocampus

1 reference

12 December 2020

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices

1 reference

12 December 2020

Membrane protein secretases

1 reference

12 December 2020

Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C.

1 reference

12 December 2020

Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain.

1 reference

12 December 2020

Glutamate receptors in the mammalian central nervous system

1 reference

12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

12 December 2020

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

12 December 2020

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

1 reference

12 December 2020

Regulation of amyloid precursor protein cleavage.

1 reference

12 December 2020

10.1523/JNEUROSCI.6017-08.2009

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357271%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference