The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation. (Q40214123)

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21 December 2019

title

The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation (English)

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21 December 2019

3

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21 December 2019

Johan Ericsson

5

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21 December 2019

author name string

Maria Simonsson

1

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21 December 2019

Meena Kanduri

2

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21 December 2019

Carl-Henrik Heldin

4

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21 December 2019

language of work or name

English

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publication date

30 October 2006

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Journal of Biological Chemistry

21 December 2019

published in

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21 December 2019

volume

281

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21 December 2019

page(s)

39870-39880

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21 December 2019

issue

52

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TGFbeta signaling in growth control, cancer, and heritable disorders

21 December 2019

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TGF-beta signal transduction

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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Specificity and versatility in tgf-beta signaling through Smads

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Regulation of gene expression by transcription factor acetylation

21 January 2018

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The many HATs of transcription coactivators

21 January 2018

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HATs on and beyond chromatin

21 January 2018

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Acetylation: a regulatory modification to rival phosphorylation?

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Histone acetyltransferases: function, structure, and catalysis

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Structure and function of histone acetyltransferases

21 January 2018

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Mammalian histone acetyltransferases and their complexes

21 January 2018

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Histone acetyltransferases

21 January 2018

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p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

21 January 2018

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Regulation of E2F1 activity by acetylation

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Regulation of transcription factor YY1 by acetylation and deacetylation

21 January 2018

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Duration of nuclear NF-kappaB action regulated by reversible acetylation

21 January 2018

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Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors.

21 January 2018

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Control of Smad7 stability by competition between acetylation and ubiquitination

21 January 2018

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MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

21 January 2018

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Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.

21 January 2018

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Regulatory cross-talk between lysine acetylation and ubiquitination: role in the control of protein stability

21 January 2018

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The balance between acetylation and deacetylation controls Smad7 stability.

21 January 2018

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Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

21 January 2018

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Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.

21 January 2018

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Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

21 January 2018

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The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling

21 January 2018

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Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

21 January 2018

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The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

21 January 2018

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TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

21 January 2018

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Role of p300, a transcriptional coactivator, in signalling of TGF-beta

21 January 2018

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TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein

21 January 2018

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Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5.

21 January 2018

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Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic.

21 January 2018

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A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

21 January 2018

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A human Mad protein acting as a BMP-regulated transcriptional activator

21 January 2018

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

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Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

21 January 2018

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Modulation of binding of DNA to the C-terminal domain of p53 by acetylation

21 January 2018

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Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation

21 January 2018

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Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation

21 January 2018

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Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor

21 January 2018

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PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

21 January 2018

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The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

21 January 2018

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Determinants of specificity in TGF-beta signal transduction.

21 January 2018

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Structural basis of Smad2 recognition by the Smad anchor for receptor activation

21 January 2018

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Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling

21 January 2018

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The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M607868200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17074756%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1 reference