TGFbeta signaling in growth control, cancer, and heritable disorders (Q28142605)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11057902%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

TGFbeta signaling in growth control, cancer, and heritable disorders (English)

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1 November 2019

1

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1 November 2019

author name string

S W Blain

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11057902%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

R S Lo

series ordinal

3

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1 November 2019

publication date

1 October 2000

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1 November 2019

language of work or name

0 references

1 reference

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1 November 2019

volume

103

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11057902%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

issue

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11057902%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

page(s)

295-309

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publication type of scholarly work

1 November 2019

review article

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Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer

1 reference

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7 January 2021

Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development

1 reference

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7 January 2021

Transforming growth factor-beta and breast cancer: Mammary gland development

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7 January 2021

Persistence of Müllerian derivatives in males

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7 January 2021

BMP type II receptor is required for gastrulation and early development of mouse embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Role of transforming growth factor beta in human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

A murine model of hereditary hemorrhagic telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian Skeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Determinants of specificity in TGF-beta signal transduction.

1 reference

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7 January 2021

A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

c-Myc target genes involved in cell growth, apoptosis, and metabolism

1 reference

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7 January 2021

Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Smads: transcriptional activators of TGF-beta responses

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Cdc25 cell-cycle phosphatase as a target of c-myc

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

A role for smad6 in development and homeostasis of the cardiovascular system

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFbetaRII.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Neural crest apoptosis and the establishment of craniofacial pattern: an honorable death

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Hereditary hemorrhagic telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Bone morphogenetic proteins: multifunctional regulators of vertebrate development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Crystal structure of the BMP-2-BRIA ectodomain complex

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Betaglycan presents ligand to the TGF beta signaling receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Expression analysis of endoglin missense and truncation mutations: insights into protein structure and disease mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

How do small GTPase signal transduction pathways regulate cell cycle entry?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Identification of two Smad4 proteins in Xenopus. Their common and distinct properties

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

High specificity of Müllerian-inhibiting substance signaling in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Genetics of ventral forebrain development and holoprosencephaly

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

TGF-β signaling, Smads, and tumor suppressors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Primary pulmonary hypertension

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Hereditary haemorrhagic telangiectasia with extensive liver involvement is not caused by either HHT1 or HHT2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Mutations in CDMP1 cause autosomal dominant brachydactyly type C

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

TGF-beta family signal transduction in Drosophila development: from Mad to Smads.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Transforming Growth Factor-β-Mediated Apoptosis in the Ramos B-Lymphoma Cell Line Is Accompanied by Caspase Activation and Bcl-XLDownregulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Nodal signalling in vertebrate development.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

A structural basis for mutational inactivation of the tumour suppressor Smad4

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

GDF5 coordinates bone and joint formation during digit development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

p53-independent role of MDM2 in TGF-beta1 resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Mutation analysis of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human colon cancer using genomic DNA and intron primers

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

A human chondrodysplasia due to a mutation in a TGF-beta superfamily member

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Smads and early developmental signaling by the TGFβ superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

A Smad transcriptional corepressor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900121-5

7 January 2021

10.1016/S0092-8674(00)00121-5

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11057902%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017