Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation (Q40170530)

18 September 2017

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation (English)

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18 September 2017

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Xian Zhang

1

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18 September 2017

Kun Zhou

2

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18 September 2017

Ruishan Wang

3

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18 September 2017

Jiankun Cui

4

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18 September 2017

Stuart A Lipton

5

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18 September 2017

Francesca-Fang Liao

6

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18 September 2017

Huaxi Xu

7

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18 September 2017

Yun-wu Zhang

8

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18 September 2017

language of work or name

English

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publication date

15 February 2007

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Journal of Biological Chemistry

18 September 2017

8

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based on heuristic

inferred from page(s)

published in

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18 September 2017

282

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18 September 2017

10873-10880

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18 September 2017

15

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Pathological and physiological functions of presenilins

18 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

The amyloid precursor protein: beyond amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

The transcription factor Yin Yang 1 is an activator of BACE1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

HIF-1: an oxygen and metal responsive transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Interactions between Alzheimer's disease and cerebral ischemia--focus on inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Risk of dementia after stroke in a hospitalized cohort: results of a longitudinal study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960-1984)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

The role of cerebral ischemia in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Expression and distribution of beta amyloid precursor protein and beta amyloid peptide in reactive astrocytes after transient middle cerebral artery occlusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Accelerated accumulation of N- and C-terminal beta APP fragments and delayed recovery of microtubule-associated protein 1B expression following stroke in aged rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Knockdown of hypoxia-inducible factor-1alpha by siRNA inhibits C2C12 myoblast differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Increased beta-secretase activity and expression in rats following transient cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Effect of ischemic neuronal insults on amyloid precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative alpha-secretases, ADAM10 and TACE, without altering their mRNA levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608856200

21 January 2018

Identifiers

DOI

10.1074/JBC.M608856200

1 reference

release_ef77lvyyvbfs3g32pn52rgmvwu

18 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ef77lvyyvbfs3g32pn52rgmvwu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference