Unravelling the mechanism of dual-specificity GAPs (Q40117233)

17 September 2017

Unravelling the mechanism of dual-specificity GAPs (English)

1 reference

17 September 2017

6

Alfred Wittinghofer

1 reference

17 September 2017

5

Klaus Gerwert

1 reference

17 September 2017

4

Yan Suveyzdis

1 reference

17 September 2017

Carsten Kötting

2

0 references

author name string

Begoña Sot

series ordinal

1

1 reference

PMCID

2857463

17 September 2017

Delia Deaconescu

series ordinal

3

1 reference

PMCID

2857463

17 September 2017

language of work or name

English

0 references

publication date

25 February 2010

1 reference

17 September 2017

1 reference

17 September 2017

29

1 reference

17 September 2017

7

1 reference

17 September 2017

1205-1214

1 reference

The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb.

17 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Consensus nomenclature for the human ArfGAP domain-containing proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Current knowledge of the large RhoGAP family of proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Theoretical IR spectroscopy based on QM/MM calculations provides changes in charge distribution, bond lengths, and bond angles of the GTP ligand induced by the Ras-protein

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

The GTPase-activating protein Rap1GAP uses a catalytic asparagine

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Targeting RAS signalling pathways in cancer therapy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Simultaneous monitoring of light-induced changes in protein side-group protonation, chromophore isomerization, and backbone motion of bacteriorhodopsin by time-resolved Fourier-transform infrared spectroscopy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Time-resolved FTIR studies of the GTPase reaction of H-ras p21 reveal a key role for the beta-phosphate.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Activation of R-Ras GTPase by GTPase-activating proteins for Ras, Gap1(m), and p120GAP.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Biological and biochemical properties of human rasH genes mutated at codon 61.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Differential regulation of rasGAP and neurofibromatosis gene product activities

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Fourier transform infrared spectroscopy on the Rap.RapGAP reaction, GTPase activation without an arginine finger

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

The Neurofibromatosis 1 Gene Product Neurofibromin Regulates Pituitary Adenylate Cyclase-Activating Polypeptide-Mediated Signaling in Astrocytes

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Rap-specific GTPase activating protein follows an alternative mechanism

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

A model-independent approach to assigning bacteriorhodopsin's intramolecular reactions to photocycle intermediates

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857463

Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice

4 November 2018

1 reference

12 December 2020

Surface Change of Ras Enabling Effector Binding Monitored in Real Time at Atomic Resolution

1 reference

12 December 2020

Catalytic domain of the p120 Ras GAP binds to RAb5 and stimulates its GTPase activity

1 reference

12 December 2020

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1 reference

12 December 2020

Time-resolved FTIR studies provide activation free energy, activation enthalpy and activation entropy for GTPase reactions

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.20

7 January 2021

inferred from DOI database lookup

New Photoactivated Protecting Groups. 6.p-Hydroxyphenacyl: A Phototrigger for Chemical and Biochemical Probes1,2

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.20

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/EMBOJ.2010.20

1 reference

17 September 2017

1 reference

17 September 2017

1 reference

PMCID

2857463