Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta (Q39664154)

13 September 2017

Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta (English)

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13 September 2017

8

Joann B Sweasy

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13 September 2017

Jen Yamtich

1

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13 September 2017

Daniela Starcevic

2

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13 September 2017

Julia Lauper

3

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13 September 2017

Elenoe Smith

4

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13 September 2017

Idina Shi

5

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13 September 2017

Sneha Rangarajan

6

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13 September 2017

Joachim Jaeger

7

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13 September 2017

language of work or name

English

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publication date

1 March 2010

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13 September 2017

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13 September 2017

49

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13 September 2017

11

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13 September 2017

2326-2334

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describes a project that uses

13 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2840207/fullTextXML

inferred from PubMed Central ID database lookup

cites work

The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates

1 reference

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Structure and mechanism of DNA polymerase Beta.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

Is base excision repair a tumor suppressor mechanism?

14 September 2017

1 reference

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Generation of mutator mutants during carcinogenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation

14 September 2017

1 reference

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Repair and genetic consequences of endogenous DNA base damage in mammalian cells

14 September 2017

1 reference

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Is there a link between DNA polymerase beta and cancer?

14 September 2017

1 reference

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AP endonuclease-independent DNA base excision repair in human cells

14 September 2017

1 reference

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A DNA polymerase beta mutant from colon cancer cells induces mutations

14 September 2017

1 reference

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Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate

14 September 2017

1 reference

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A mutator phenotype in cancer.

14 September 2017

1 reference

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The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

14 September 2017

1 reference

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A genetic system to identify DNA polymerase beta mutator mutants

14 September 2017

1 reference

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DNA polymerase beta: structure-fidelity relationship from Pre-steady-state kinetic analyses of all possible correct and incorrect base pairs for wild type and R283A mutant

14 September 2017

1 reference

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VMD: visual molecular dynamics

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

DNA polymerase beta: pre-steady-state kinetic analysis and roles of arginine-283 in catalysis and fidelity.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

DNA polymerase beta: analysis of the contributions of tyrosine-271 and asparagine-279 to substrate specificity and fidelity of DNA replication by pre-steady-state kinetics

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840207

Hydrophobic interactions in the hinge domain of DNA polymerase beta are important but not sufficient for maintaining fidelity of DNA synthesis

21 August 2018

1 reference

12 December 2020

DNA polymerase beta: contributions of template-positioning and dNTP triphosphate-binding residues to catalysis and fidelity

1 reference

12 December 2020

Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity

1 reference

12 December 2020

Characterization of DNA polymeraseβ mutants with amino acid substitutions located in the C-terminal portion of the enzyme

1 reference

12 December 2020

The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors

1 reference

12 December 2020

Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates

1 reference

12 December 2020

Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator

1 reference

12 December 2020

Identifiers

DOI

10.1021/BI901735A

1 reference

13 September 2017

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13 September 2017

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