A DNA polymerase beta mutant from colon cancer cells induces mutations (Q37646895)

21 August 2017

A DNA polymerase beta mutant from colon cancer cells induces mutations (English)

1 reference

21 August 2017

1 reference

5

Joann B Sweasy

1 reference

21 August 2017

Tieming Lang

1

1 reference

21 August 2017

Mausumi Maitra

series ordinal

2

1 reference

21 August 2017

Daniela Starcevic

series ordinal

3

1 reference

21 August 2017

Shu-Xia Li

series ordinal

4

1 reference

21 August 2017

language of work or name

English

0 references

publication date

9 April 2004

1 reference

Proceedings of the National Academy of Sciences of the United States of America

21 August 2017

1 reference

21 August 2017

101

1 reference

21 August 2017

16

1 reference

21 August 2017

6074-6079

1 reference

APC, signal transduction and genetic instability in colorectal cancer

21 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Keynote: past, present, and future aspects of base excision repair

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

A novel role of XRCC1 in the functions of a DNA polymerase beta variant

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

A role for p53 in base excision repair.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

A variant of DNA polymerase beta acts as a dominant negative mutant

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Instability and decay of the primary structure of DNA

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Detection and analysis of UV-induced mutations in mammalian cell DNA using a lambda phage shuttle vector

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

DNA polymerase beta mutations in human colorectal cancer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Energetics and specificity of Rat DNA polymerase beta interactions with template-primer and gapped DNA substrates

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

The E249K mutator mutant of DNA polymerase beta extends mispaired termini

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Delayed DNA joining at 3' mismatches by human DNA ligases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Progress toward molecular biology of DNA polymerase beta

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

High efficiency, restriction-deficient in vitro packaging extracts for bacteriophage lambda DNA using a new E.coli lysogen

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Implication of p53 in base excision DNA repair: in vivo evidence

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Requirement of mammalian DNA polymerase-beta in base-excision repair.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Statistical test for the comparison of samples from mutational spectra

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Functional mutation of DNA polymerase beta found in human gastric cancer--inability of the base excision repair in vitro.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

DNA polymerase beta gene mutation in human prostate cancer.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Kinetic analysis of base substitution mutagenesis by transient misalignment of DNA and by miscoding

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Variant forms of DNA polymerase beta in primary lung carcinomas.

25 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308571101

Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308571101

Abasic translesion synthesis by DNA polymerase beta violates the "A-rule". Novel types of nucleotide incorporation by human DNA polymerase beta at an abasic lesion in different sequence contexts

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308571101

Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humans.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

The DNA polymerase beta replication error spectrum in the adenomatous polyposis coli gene contains human colon tumor mutational hotspots.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395925

Alteration of hMSH2 and DNA polymerase beta genes in breast carcinomas and fibroadenomas

1 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308571101

Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308571101

Minor groove interactions at the DNA polymerase beta active site modulate single-base deletion error rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308571101

Frequent spontaneous deletions at a shuttle vector locus in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308571101

Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308571101

The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308571101

Hypermutability to ionizing radiation in mismatch repair-deficient, Pms2 knockout mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15075389

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fluorescence in situ hybridization analysis of 8p allelic loss and chromosome 8 instability in human prostate cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15075389

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Reduced fidelity of DNA synthesis in cell extracts from chemically induced primary thymic lymphomas of mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15075389

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0308571101

1 reference

21 August 2017

0 references

1 reference

21 August 2017

1 reference