Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2. (Q39616232)

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18 January 2020

title

Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2 (English)

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18 January 2020

12

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9

Zdenek Hostomsky

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18 January 2020

author name string

Yvette Drew

1

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18 January 2020

Evan A Mulligan

2

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18 January 2020

Wan-Tse Vong

3

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18 January 2020

Huw D Thomas

4

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18 January 2020

Samra Kahn

5

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18 January 2020

Suzanne Kyle

6

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18 January 2020

Asima Mukhopadhyay

7

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18 January 2020

Gerrit Los

8

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18 January 2020

Elizabeth R Plummer

10

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18 January 2020

Richard J Edmondson

11

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18 January 2020

language of work or name

English

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publication date

23 December 2010

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Journal of the National Cancer Institute

18 January 2020

published in

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18 January 2020

volume

103

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18 January 2020

issue

4

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18 January 2020

page(s)

334-346

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Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

18 January 2020

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The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair

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Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

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Triple-negative breast cancer: therapeutic options

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BRCA1 dysfunction in sporadic basal-like breast cancer

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EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

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Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by poly(ADP-ribose) polymerase inhibition

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BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants

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BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells

21 January 2018

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BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy

21 January 2018

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

21 January 2018

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New colorimetric cytotoxicity assay for anticancer-drug screening

21 January 2018

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Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

21 January 2018

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

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21 January 2018

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In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor

21 January 2018

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High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

21 January 2018

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Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

21 January 2018

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21 January 2018

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