A nine amino acid domain is essential for mutant prion protein toxicity (Q39486840)

12 September 2017

A nine amino acid domain is essential for mutant prion protein toxicity (English)

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12 September 2017

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3

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author name string

Laura Westergard

series ordinal

1

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12 September 2017

Jessie A Turnbaugh

series ordinal

2

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12 September 2017

language of work or name

English

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publication date

1 September 2011

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12 September 2017

Journal of Neuroscience

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12 September 2017

31

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12 September 2017

39

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12 September 2017

14005-14017

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describes a project that uses

12 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3227396/fullTextXML

inferred from PubMed Central ID database lookup

cites work

An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Structure of the Flexible Amino-Terminal Domain of Prion Protein Bound to a Sulfated Glycan

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Prion neurotoxicity: insights from prion protein mutants

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Pathologic prion protein infects cells by lipid-raft dependent macropinocytosis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Lethal recessive myelin toxicity of prion protein lacking its central domain

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

New insights into prion structure and toxicity.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Mammalian prion biology: one century of evolving concepts

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Cell-surface prion protein interacts with glycosaminoglycans

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Chlorate--a potent inhibitor of protein sulfation in intact cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

A deleted prion protein that is neurotoxic in vivo is localized normally in cultured cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Characterization and polyanion-binding properties of purified recombinant prion protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Molecular modeling of protein-glycosaminoglycan interactions.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Identification of the heparan sulfate binding sites in the cellular prion protein

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Truncated forms of the human prion protein in normal brain and in prion diseases.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227396

Dominant-negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein

21 August 2018

1 reference

12 December 2020

Identification of two prion protein regions that modify scrapie incubation time

1 reference

12 December 2020

Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.

1 reference

12 December 2020

Identification of cryptic nuclear localization signals in the prion protein.

1 reference

12 December 2020

Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration

1 reference

12 December 2020

Microtubules-associated intracellular localization of the NH2-terminal cellular prion protein fragment

1 reference

12 December 2020

Anterograde and retrograde intracellular trafficking of fluorescent cellular prion protein

1 reference

12 December 2020

Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region

1 reference

12 December 2020

Toward molecular dissection of PrPC-PrPSc interactions

1 reference

12 December 2020

Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein/doppel in mice

1 reference

12 December 2020

The polybasic N-terminal region of the prion protein controls the physical properties of both the cellular and fibrillar forms of PrP.

1 reference

12 December 2020

Selective processing and metabolism of disease-causing mutant prion proteins

1 reference

12 December 2020

Antimicrobial activity of human prion protein is mediated by its N-terminal region

1 reference

12 December 2020

Glypican-1 mediates both prion protein lipid raft association and disease isoform formation

1 reference

12 December 2020

The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits

1 reference

12 December 2020

A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells

1 reference

12 December 2020

A vector for expressing foreign genes in the brains and hearts of transgenic mice

1 reference

12 December 2020

10.1523/JNEUROSCI.1243-11.2011

Identifiers

DOI

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release_eaowsbznofaghe72oog34peduq

12 September 2017

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Fatcat

https://api.fatcat.wiki/v0/release/eaowsbznofaghe72oog34peduq

24 November 2022

mapped directly with Wikidata item

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12 September 2017

PubMed publication ID

21957261

1 reference