Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells (Q34074520)

30 July 2017

Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells (English)

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30 July 2017

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Isaac H Solomon

1

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30 July 2017

James E Huettner

series ordinal

2

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30 July 2017

David A Harris

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

23 June 2010

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Journal of Biological Chemistry

30 July 2017

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30 July 2017

285

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30 July 2017

34

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30 July 2017

26719-26726

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A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Functionally relevant domains of the prion protein identified in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Pathologic prion protein infects cells by lipid-raft dependent macropinocytosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

A deleted prion protein that is neurotoxic in vivo is localized normally in cultured cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

PrP(106-126) does not interact with membranes under physiological conditions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

The cellular prion protein (PrP(C)): its physiological function and role in disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Lethal recessive myelin toxicity of prion protein lacking its central domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

New insights into prion structure and toxicity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

5 July 2018

Prion disease genetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Q/R site editing controls kainate receptor inhibition by membrane fatty acids.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Anchorless prion protein results in infectious amyloid disease without clinical scrapie

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

TRPV1 regulators mediate gentamicin penetration of cultured kidney cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

HEK293 cell line: a vehicle for the expression of recombinant proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Hippocampal synaptic plasticity in mice devoid of cellular prion protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Lentiviral vectors for the delivery of DNA into mammalian cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Neuroprotective functions of prion protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Toxicological and cytophysiological aspects of lanthanides action

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Prion diseases: what is the neurotoxic molecule?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic Reticulum.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Gain of function mutants: ion channels and G protein-coupled receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Properties of cytotoxic peptide-formed ion channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Prion protein NMR structure and familial human spongiform encephalopathies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

A transmembrane form of the prion protein in neurodegenerative disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Channel formation by a neurotoxic prion protein fragment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Endogenous chloride channels of insect sf9 cells. Evidence for coordinated activity of small elementary channel units.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Molecular location of a species-specific epitope on the hamster scrapie agent protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924115

Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.

5 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

Gap junctions and connexon hemichannels in human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

Identification of the heparan sulfate binding sites in the cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

A novel pathway determining multidrug sensitivity in Schizosaccharomyces pombe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

Neurotoxicity of a prion protein fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

Prion peptide fragment PrP[106-126] forms distinct cation channel types.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

The toxicity of prion protein fragment PrP(106-126) is not mediated by membrane permeabilization as shown by a M112W substitution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

The effect of disease-associated mutations on the folding pathway of human prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

Normal host prion protein necessary for scrapie-induced neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

Vesicle permeabilization by purified soluble oligomers of prion protein: a comparative study of the interaction of oligomers and monomers with lipid membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

Prion protein is necessary for normal synaptic function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

Prion protein affects Ca2+-activated K+ currents in cerebellar purkinje cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134619

Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20573963

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.134619

1 reference

30 July 2017

1 reference

30 July 2017

1 reference