An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity (Q34800606)

4 August 2017

An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity (English)

1 reference

4 August 2017

0 references

Emiliano Biasini

3

1 reference

ORCID Public Data File 2021

author name string

Isaac H Solomon

1

1 reference

4 August 2017

Natasha Khatri

2

1 reference

4 August 2017

Tania Massignan

4

1 reference

4 August 2017

James E Huettner

5

1 reference

4 August 2017

David A Harris

6

1 reference

4 August 2017

language of work or name

English

0 references

publication date

8 March 2011

1 reference

Journal of Biological Chemistry

4 August 2017

1 reference

4 August 2017

286

1 reference

4 August 2017

16

1 reference

4 August 2017

14724-14736

1 reference

A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

The hydrophobic core region governs mutant prion protein aggregation and intracellular retention

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Axonal prion protein is required for peripheral myelin maintenance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Antimicrobial activity of human prion protein is mediated by its N-terminal region

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Functionally relevant domains of the prion protein identified in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Pathologic prion protein infects cells by lipid-raft dependent macropinocytosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

A deleted prion protein that is neurotoxic in vivo is localized normally in cultured cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Mechanism of the metal-mediated endocytosis of the prion protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Lethal recessive myelin toxicity of prion protein lacking its central domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

New insights into prion structure and toxicity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

8 July 2018

Prion disease genetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Q/R site editing controls kainate receptor inhibition by membrane fatty acids.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Anchorless prion protein results in infectious amyloid disease without clinical scrapie

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

TRPV1 regulators mediate gentamicin penetration of cultured kidney cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

The AGAAAAGA palindrome in PrP is required to generate a productive PrPSc-PrPC complex that leads to prion propagation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Hippocampal synaptic plasticity in mice devoid of cellular prion protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Prion channel proteins and their role in vacuolation and neurodegenerative diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Differential sorting and fate of endocytosed GPI-anchored proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Mutant prion proteins are partially retained in the endoplasmic reticulum

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Crystal structure of the human prion protein reveals a mechanism for oligomerization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Copper stimulates endocytosis of the prion protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Prion protein NMR structure and familial human spongiform encephalopathies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Prion (PrPSc)-specific epitope defined by a monoclonal antibody

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Mutant and infectious prion proteins display common biochemical properties in cultured cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Mice devoid of PrP are resistant to scrapie

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Targeting of a heterodimeric membrane protein complex to the Golgi: rubella virus E2 glycoprotein contains a transmembrane Golgi retention signal

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Scrapie prion protein contains a phosphatidylinositol glycolipid

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Molecular location of a species-specific epitope on the hamster scrapie agent protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Normal host prion protein necessary for scrapie-induced neurotoxicity.

8 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Gap junctions and connexon hemichannels in human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Identification of the heparan sulfate binding sites in the cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Prion protein is necessary for normal synaptic function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Prion protein affects Ca2+-activated K+ currents in cerebellar purkinje cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

The effect of disease-associated mutations on the folding pathway of human prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

A novel mutation (G114V) in the prion protein gene in a family with inherited prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Toward molecular dissection of PrPC-PrPSc interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

Gentamicin traffics rapidly and directly to the Golgi complex in LLC-PK(1) cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077669

Monoclonal antibodies inhibit prion replication and delay the development of prion disease

26 October 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.214973

The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21385869

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.214973

1 reference

4 August 2017

1 reference

4 August 2017

1 reference