Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells (Q39443134)

12 September 2017

Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells (English)

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12 September 2017

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Oshrat Attar-Schneider

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12 September 2017

Liat Drucker

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12 September 2017

Victoria Zismanov

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12 September 2017

Shelly Tartakover-Matalon

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12 September 2017

Gloria Rashid

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12 September 2017

Michael Lishner

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12 September 2017

language of work or name

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14 November 2011

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12 September 2017

Laboratory Investigation

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12 September 2017

92

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12 September 2017

2

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12 September 2017

178-190

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https://scigraph.springernature.com/pub.10.1038/labinvest.2011.162

12 September 2017

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

PI3-K/AKT/FKHR and MAPK signaling cascades are redundantly stimulated by a variety of cytokines and contribute independently to proliferation and survival of multiple myeloma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Taking aim at translation for tumor therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

c-Myc and eIF4F are components of a feedforward loop that links transcription and translation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Initiation of mRNA translation in oncogenesis: the role of eIF4E.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Translational control of the proteome: relevance to cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Response to trastuzumab, erlotinib, and bevacizumab, alone and in combination, is correlated with the level of human epidermal growth factor receptor-2 expression in human breast cancer cell lines

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Cell culture detection of microvascular cell death in clinical specimens of human neoplasms and peripheral blood

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Co-administration of simvastatin and cytotoxic drugs is advantageous in myeloma cell lines

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Tetraspanins affect myeloma cell fate via Akt signaling and FoxO activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Intravenous immunoglobulins--understanding properties and mechanisms

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Tumor angiogenesis in the bone marrow of multiple myeloma patients and its alteration by thalidomide treatment

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Targeting the translational machinery as a novel treatment strategy for hematologic malignancies

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Sumoylation of eIF4E activates mRNA translation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Methods for studying signal-dependent regulation of translation factor activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Is cell death a critical end point for anticancer therapies or is cytostasis sufficient?

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Mechanisms of cell death and survival in multiple myeloma (MM): Therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Activation of AKT kinases in cancer: implications for therapeutic targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Protein kinase ERK contributes to differential responsiveness of human myeloma cell lines to IFNalpha

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

mTOR: a protein kinase switching between life and death

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Expression of VEGF and its receptors by myeloma cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

Fetal stromal-dependent paracrine and intracrine vascular endothelial growth factor-a/vascular endothelial growth factor receptor-1 signaling promotes proliferation and motility of human primary myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

7 January 2021

Molecular aspects of multiple myeloma

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

7 January 2021

Inhibition of VEGF induces cellular senescence in colorectal cancer cells

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

7 January 2021

Overexpression of tetraspanins affects multiple myeloma cell survival and invasive potential

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https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

7 January 2021

Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.162

7 January 2021

10.1038/LABINVEST.2011.162

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DOI

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12 September 2017

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