It's T-ALL about Notch (Q37256435)

19 August 2017

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title

It's T-ALL about Notch (English)

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19 August 2017

R M Demarest

1

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19 August 2017

F Ratti

series ordinal

2

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19 August 2017

A J Capobianco

series ordinal

3

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19 August 2017

language of work or name

English

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publication date

1 September 2008

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19 August 2017

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19 August 2017

27

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19 August 2017

5082-5091

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19 August 2017

38

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https://scigraph.springernature.com/pub.10.1038/onc.2008.222

19 August 2017

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cites work

Molecular pathogenesis of T-cell leukaemia and lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

21 January 2018

Myc and the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch and Ikaros: not only converging players in T cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Targeting promiscuous signaling pathways in cancer: another Notch in the bedpost

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

p53 ubiquitination: Mdm2 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Function of the c-Myc oncogenic transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

The suppressor of hairless protein participates in notch receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

The Ikaros gene is required for the development of all lymphoid lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Childhood T-Cell Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Structural basis for autoinhibition of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Mediation of c-Myc-induced apoptosis by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch and cancer: a double-edged sword

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

The P53 pathway: what questions remain to be explored?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Defective expression of Notch1 and Notch2 in connection to alterations of c-Myc and Ikaros in gamma-radiation-induced mouse thymic lymphomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

myc function and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch signaling: from the outside in

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch1 functions as a tumor suppressor in mouse skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch(ic)-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

The multifaceted role of Notch in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Roles for c-Myc in self-renewal of hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Cyclin E-CDK2 is a regulator of p27Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Divorcing ARF and p53: an unsettled case

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Requirement for cyclin D3 in lymphocyte development and T cell leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Notch1-induced transformation of RKE-1 cells requires up-regulation of cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Nuclear access and action of notch in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

RBP-J kappa repression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

Down-regulation of p27Kip1 expression is required for development and function of T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.222

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.222

1 reference

19 August 2017

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