Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1. (Q39207731)

10 September 2017

Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1. (English)

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10 September 2017

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P Wang

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10 September 2017

L Chen

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10 September 2017

J Zhang

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10 September 2017

H Chen

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10 September 2017

J Fan

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10 September 2017

K Wang

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10 September 2017

J Luo

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10 September 2017

Z Chen

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10 September 2017

Z Meng

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10 September 2017

L Liu

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10 September 2017

language of work or name

English

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publication date

21 January 2013

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33

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4

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514-524

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https://scigraph.springernature.com/pub.10.1038/onc.2012.598

10 September 2017

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MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma

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Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development

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The silencing of microRNA 148a production by DNA hypermethylation is an early event in pancreatic carcinogenesis.

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Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer

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Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer

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miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma

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The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2.

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Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer.

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DNA methylation profiling of human chromosomes 6, 20 and 22

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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

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Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion

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Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells

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Epigenetics and cancer

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MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor

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miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer.

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Epigenetic silencing of microRNA-34b/c plays an important role in the pathogenesis of malignant pleural mesothelioma.

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DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect

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An essential role for Rac in Ras transformation

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Role of Rho GTPases and their regulators in cancer progression

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Early requirement of Rac1 in a mouse model of pancreatic cancer.

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MicroRNAs: novel diagnostic and therapeutic tools for pancreatic ductal adenocarcinoma?

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Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival

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MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis

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MicroRNAs: predictors and modifiers of chemo- and radiotherapy in different tumour types

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Sensitivity and accuracy of quantitative real-time polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions

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Identification of liver metastasis-related genes in a novel human pancreatic carcinoma cell model by microarray analysis

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Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells

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MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity

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CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.

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A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with their putative targets

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The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS.

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Inhibiting microRNA function in vivo

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Full-dose gemcitabine and concurrent radiotherapy for unresectable pancreatic cancer

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Patterns of failure after curative resection of pancreatic carcinoma

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2012.598

1 reference

10 September 2017

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