Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment (Q39045906)

8 September 2017

Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment (English)

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8 September 2017

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Krystyna Skalicka-Woźniak

8 September 2017

4

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Maria Daglia

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object named as

Maria Daglia

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8 September 2017

Carmela Spagnuolo

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8 September 2017

Gian Luigi Russo

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8 September 2017

Eduardo Sobarzo-Sánchez

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8 September 2017

Seyed Fazel Nabavi

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8 September 2017

Seyed Mohammad Nabavi

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8 September 2017

21 December 2016

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Critical Reviews in Food Science and Nutrition

8 September 2017

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8 September 2017

1-15

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Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines.

8 September 2017

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

A derivatization method for the simultaneous detection of glucosinolates and isothiocyanates in biological samples.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Multi-targeted prevention of cancer by sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Antileukemic activity of sulforaphane in primary blasts from patients affected by myelo- and lympho-proliferative disorders and in hypoxic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Separation and purification of sulforaphane from broccoli by solid phase extraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Methylation of the KEAP1 gene promoter region in human colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Hallmarks of Cancer: The Next Generation

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Growth inhibition and apoptosis of neuroblastoma cells through ROS-independent MEK/ERK activation by sulforaphane

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

The complexity of the Nrf2 pathway: beyond the antioxidant response

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane inhibits oral carcinoma cell migration and invasion in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Fruit and vegetable intake in relation to risk of ischemic stroke.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Nrf2: friend or foe for chemoprevention?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Fruit and vegetables and cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/β-catenin signaling in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane controls TPA-induced MMP-9 expression through the NF-κB signaling pathway, but not AP-1, in MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane as a promising molecule for fighting cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane inhibits mammary adipogenesis by targeting adipose mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Application of high-speed countercurrent chromatography for the isolation of sulforaphane from broccoli seed meal

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/β-catenin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Nrf2 sensitizes prostate cancer cells to radiation via decreasing basal ROS levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

A genomic screen for activators of the antioxidant response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) - study protocol for a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

The Dual Roles of NRF2 in Cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Nrf2: friend and foe in preventing cigarette smoking-dependent lung disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane protects rodent retinas against ischemia-reperfusion injury through the activation of the Nrf2/HO-1 antioxidant pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane inhibits growth of phenotypically different breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Ins and outs of dietary phytochemicals in cancer chemoprevention.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Phytochemicals in cancer prevention and therapy: truth or dare?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Inhibition of benzo[a]pyrene- and 1,6-dinitropyrene-DNA adduct formation in human mammary epithelial cells bydibenzoylmethane and sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Chemoprevention: an essential approach to controlling cancer

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-κB Signaling Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane as a potential protective phytochemical against neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Evaluation of protective effects of sulforaphane on DNA damage caused by exposure to low levels of pesticide mixture using comet assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study: The Netherlands Cohort Study on Diet and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Impact of thermal processing on sulforaphane yield from broccoli ( Brassica oleracea L. ssp. italica).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Telomere biology in aging and cancer.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Substantial contribution of extrinsic risk factors to cancer development

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Nrf2: bane or blessing in cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane inhibits PDGF-induced proliferation of rat aortic vascular smooth muscle cell by up-regulation of p53 leading to G1/S cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Germline Mutations in Predisposition Genes in Pediatric Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Novel gram-scale production of enantiopure R-sulforaphane from Tuscan black kale seeds

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

Sulforaphane protects human chondrocytes against cell death induced by various stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408398.2016.1259983

10.1080/10408398.2016.1259983

21 January 2018

Identifiers

DOI

1 reference

8 September 2017

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