Alternative splicing and cell survival: from tissue homeostasis to disease (Q38968877)

21 May 2018

review article

1 reference

title

Alternative splicing and cell survival: from tissue homeostasis to disease (English)

1 reference

21 May 2018

alternative mRNA splicing, via spliceosome

main subject

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1 reference

3

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21 May 2018

author name string

Maria Paola Paronetto

series ordinal

1

1 reference

21 May 2018

Ilaria Passacantilli

series ordinal

2

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21 May 2018

publication date

30 September 2016

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21 May 2018

Cell Death & Differentiation

published in

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21 May 2018

volume

23

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21 May 2018

page(s)

1919-1929

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21 May 2018

issue

12

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21 May 2018

https://scigraph.springernature.com/pub.10.1038/cdd.2016.91

exact match

0 references

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The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7

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SAM68: Signal Transduction and RNA Metabolism in Human Cancer

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Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells.

17 June 2018

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Consequence of the tumor-associated conversion to cyclin D1b

17 June 2018

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17 June 2018

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Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5' splice site selection

17 June 2018

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Cell biology. Metabolic control of cell death

17 June 2018

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The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression

17 June 2018

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Splice variants of MDM2 in oncogenesis

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Context-dependent control of alternative splicing by RNA-binding proteins

17 June 2018

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Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis

17 June 2018

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Regulation of FAS exon definition and apoptosis by the Ewing sarcoma protein

17 June 2018

1 reference

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FAS-antisense 1 lncRNA and production of soluble versus membrane Fas in B-cell lymphoma.

17 June 2018

1 reference

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The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis

17 June 2018

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Alternative splicing in cancer: implications for biology and therapy

17 June 2018

1 reference

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The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival

17 June 2018

1 reference

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Misregulation of pre-mRNA alternative splicing in cancer

17 June 2018

1 reference

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Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins

17 June 2018

1 reference

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Signals from the lysosome: a control centre for cellular clearance and energy metabolism

17 June 2018

1 reference

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hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L

17 June 2018

1 reference

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NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers

17 June 2018

1 reference

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Autophagy is differentially induced in prostate cancer LNCaP, DU145 and PC-3 cells via distinct splicing profiles of ATG5.

17 June 2018

1 reference

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Antisense-based therapy for the treatment of spinal muscular atrophy

17 June 2018

1 reference

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BaxΔ2 is a novel bax isoform unique to microsatellite unstable tumors

17 June 2018

1 reference

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Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway.

17 June 2018

1 reference

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17 June 2018

1 reference

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Regulation of chemoresistance via alternative messenger RNA splicing

17 June 2018

1 reference

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Treatment of HER2-positive breast cancer: current status and future perspectives.

17 June 2018

1 reference

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Autophagy: renovation of cells and tissues

17 June 2018

1 reference

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The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator

17 June 2018

1 reference

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Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

17 June 2018

1 reference

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Mitochondria and the autophagy-inflammation-cell death axis in organismal aging

17 June 2018

1 reference

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SRSF1 regulates the alternative splicing of caspase 9 via a novel intronic splicing enhancer affecting the chemotherapeutic sensitivity of non-small cell lung cancer cells

17 June 2018

1 reference

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The RNA-binding protein Sam68 is a multifunctional player in human cancer

17 June 2018

1 reference

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Alternative cell death mechanisms in development and beyond

17 June 2018

1 reference

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Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance

17 June 2018

1 reference

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Cotranscriptional exon skipping in the genotoxic stress response

17 June 2018

1 reference

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hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing

17 June 2018

1 reference

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Anti-tumor activity of splice-switching oligonucleotides

17 June 2018

1 reference

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An alternative splicing network links cell-cycle control to apoptosis

17 June 2018

1 reference

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Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs

17 June 2018

1 reference

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Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene

17 June 2018

1 reference

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Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin.

17 June 2018

1 reference

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Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68

17 June 2018

1 reference

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

17 June 2018

1 reference

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17 June 2018

1 reference

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17 June 2018

1 reference

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17 June 2018

1 reference

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Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-xS splice isoform

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

The spliceosome: design principles of a dynamic RNP machine

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

The cyclin D1b splice variant: an old oncogene learns new tricks

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

SAP155 Binds to ceramide-responsive RNA cis-element 1 and regulates the alternative 5' splice site selection of Bcl-x pre-mRNA.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Genetic disorders of programmed cell death in the immune system

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Regulation of apoptosis by alternative pre-mRNA splicing

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

DeltaNp73beta is active in transactivation and growth suppression.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Mechanisms of alternative pre-messenger RNA splicing

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Signal-dependent regulation of splicing via phosphorylation of Sam68

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Cellular response to an antisense-mediated shift of Bcl-x pre-mRNA splicing and antineoplastic agents

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

CD95's deadly mission in the immune system

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

The splicing factor U1C represses EWS/FLI-mediated transactivation

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Caspase-9 and APAF-1 form an active holoenzyme

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Apoptotic pathways: the roads to ruin

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

17 June 2018

Caspases: enemies within

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

An additional form of rat Bcl-x, Bcl-xbeta, generated by an unspliced RNA, promotes apoptosis in promyeloid cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

ICE-like proteases in apoptosis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Cell death during development of the nervous system

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

BaxΔ2 promotes apoptosis through caspase-8 activation in microsatellite-unstable colon cancer

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

A comparison of the expression and properties of Apaf-1 and Apaf-1L.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5136496

Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival

21 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.91

7 January 2021

Genome-wide identification of Fas/CD95 alternative splicing regulators reveals links with iron homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.91

7 January 2021

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.91

7 January 2021

Heterogeneous nuclear ribonucleoprotein F/H proteins modulate the alternative splicing of the apoptotic mediator Bcl-x

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.91

7 January 2021

Antagonistic effects of the SRp30c protein and cryptic 5' splice sites on the alternative splicing of the apoptotic regulator Bcl-x

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.91

7 January 2021

Programmed cell death induced by ceramide

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.91

7 January 2021

Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.91

7 January 2021

Identifiers

DOI

10.1038/CDD.2016.91

1 reference

21 May 2018

Dimensions Publication ID

0 references

1 reference

21 May 2018

PubMed ID

27689872

1 reference

21 May 2018