Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity? (Q38958106)

http://europepmc.org/abstract/PMC/5303663

15 June 2018

review article

1 reference

title

Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity? (English)

1 reference

http://europepmc.org/abstract/PMC/5303663

15 June 2018

0 references

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27641664%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Elena Popugaeva

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27641664%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Ekaterina Pchitskaya

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27641664%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

language of work or name

English

0 references

publication date

15 September 2016

1 reference

http://europepmc.org/abstract/PMC/5303663

15 June 2018

published in

Biochemical and Biophysical Research Communications

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27641664%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

483

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31 May 2020

page(s)

998-1004

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27641664%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27641664%20AND%20SRC:MED&resulttype=core&format=json

Emerging pathways driving early synaptic pathology in Alzheimer's disease

31 May 2020

cites work

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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Physiological Function and Characterization of TRPCs in Neurons

17 June 2018

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Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice

17 June 2018

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The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

17 June 2018

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Calcium channelopathies and Alzheimer's disease: insight into therapeutic success and failures

17 June 2018

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Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease

17 June 2018

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Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

17 June 2018

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The neglected CRAC proteins: Orai2, Orai3, and STIM2.

17 June 2018

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Presenilins and calcium signaling-systems biology to the rescue

17 June 2018

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17 June 2018

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Native STIM2 and ORAI1 proteins form a calcium-sensitive and thapsigargin-insensitive complex in cortical neurons

17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease

17 June 2018

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Neural functions of calcineurin in synaptic plasticity and memory

17 June 2018

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Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing.

17 June 2018

1 reference

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A role for calcineurin in Alzheimer's disease

17 June 2018

1 reference

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Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations

17 June 2018

1 reference

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Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

17 June 2018

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17 June 2018

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Mechanisms of CaMKII action in long-term potentiation

17 June 2018

1 reference

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Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels

17 June 2018

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Measuring CaMKII concentration in dendritic spines

17 June 2018

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Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease

17 June 2018

1 reference

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Alzheimer's disease: synapses gone cold

17 June 2018

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17 June 2018

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17 June 2018

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Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease

17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture

17 June 2018

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Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes

17 June 2018

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Role of presenilins in neuronal calcium homeostasis

17 June 2018

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CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage

17 June 2018

1 reference

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Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice

17 June 2018

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Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons

17 June 2018

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Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

17 June 2018

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17 June 2018

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The dysregulation of intracellular calcium in Alzheimer disease

17 June 2018

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The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model

17 June 2018

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Up-regulation of the type 3 ryanodine receptor is neuroprotective in the TgCRND8 mouse model of Alzheimer's disease

17 June 2018

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Thin, stubby or mushroom: spine pathology in Alzheimer's disease

17 June 2018

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The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

17 June 2018

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Activation of CaMKII in single dendritic spines during long-term potentiation

17 June 2018

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Calcium signaling and neurodegenerative diseases

17 June 2018

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Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition

17 June 2018

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Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

17 June 2018

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

17 June 2018

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An allosteric model of calmodulin explains differential activation of PP2B and CaMKII

17 June 2018

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Linking calcium to Abeta and Alzheimer's disease

17 June 2018

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SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production

17 June 2018

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Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

17 June 2018

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Balancing structure and function at hippocampal dendritic spines

17 June 2018

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Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels

17 June 2018

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Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice

17 June 2018

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Do thin spines learn to be mushroom spines that remember?

17 June 2018

1 reference

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Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice

17 June 2018

1 reference

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Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits

17 June 2018

1 reference

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alphaCaMKII autophosphorylation: a fast track to memory

17 June 2018

1 reference

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The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis

17 June 2018

1 reference

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Dantrolene--a review of its pharmacology, therapeutic use and new developments

17 June 2018

1 reference

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Structure-stability-function relationships of dendritic spines

17 June 2018

1 reference

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

17 June 2018

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Alzheimer's disease is a synaptic failure

17 June 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

17 June 2018

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The molecular basis of CaMKII function in synaptic and behavioural memory

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Alzheimer's disease: the amyloid cascade hypothesis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

The role of the store-operated calcium entry channel Orai1 in cultured rat hippocampal synapse formation and plasticity.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Single App knock-in mouse models of Alzheimer's disease.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Can the calcium hypothesis explain synaptic loss in Alzheimer's disease?

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Calcineurin inhibition rescues early synaptic plasticity deficits in a mouse model of Alzheimer's disease.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Response to Shilling et al. (10.1074/jbc.M111.300491).

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Calcium signalling and Alzheimer's disease.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Critical role of TRPC6 channels in the formation of excitatory synapses.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein-protein interaction

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5303663

Presenilin-mediated modulation of capacitative calcium entry

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27641664

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27641664

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BBRC.2016.09.053

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27641664%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27641664%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference