Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma (Q38917883)

7 September 2017

Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma (English)

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7 September 2017

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23

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31 May 2020

Agrin Moeini

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Roser Pinyol

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Vincenzo Mazzaferro

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Eric Schadt

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Carlos Cordon-Cardo

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31 May 2020

Mireia Castillo-Martin

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Mireia Castillo-Martin

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31 May 2020

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Daniela Sia

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31 May 2020

Bojan Losic

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Laia Cabellos

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31 May 2020

Ke Hao

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31 May 2020

Kate Revill

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Dennis Bonal

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Oriana Miltiadous

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Zhongyang Zhang

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Yujin Hoshida

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Helena Cornella

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Yumi Kasai

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Sasan Roayaie

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Swan N Thung

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Josep Fuster

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Myron E Schwartz

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Samuel Waxman

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language of work or name

English

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publication date

22 January 2015

1 reference

7 September 2017

Nature Communications

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31 May 2020

volume

6

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page(s)

6087

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https://scigraph.springernature.com/pub.10.1038/ncomms7087

31 May 2020

exact match

0 references

cites work

Pathogenesis, diagnosis, and management of cholangiocarcinoma

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7 January 2021

Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma

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Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer

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Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies

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7 January 2021

Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes

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7 January 2021

Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors

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7 January 2021

Exome sequencing of liver fluke-associated cholangiocarcinoma

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7 January 2021

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

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7 January 2021

Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers

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7 January 2021

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups

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7 January 2021

Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions

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7 January 2021

Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies

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7 January 2021

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

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7 January 2021

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

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7 January 2021

ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex

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7 January 2021

Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.

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7 January 2021

Identification of targetable FGFR gene fusions in diverse cancers.

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7 January 2021

Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma

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7 January 2021

Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

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7 January 2021

New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing

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7 January 2021

Fibroblast growth factor signalling: from development to cancer

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7 January 2021

Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope

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7 January 2021

Human chromosome fragility

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Molecular basis for expression of common and rare fragile sites

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7 January 2021

Role of DNA secondary structures in fragile site breakage along human chromosome 10

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7 January 2021

Interplay between ATM and ATR in the regulation of common fragile site stability

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7 January 2021

Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma

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7 January 2021

Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

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7 January 2021

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

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7 January 2021

Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma.

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7 January 2021

ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers

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7 January 2021

Mutational analysis of the ARAF gene in human cancers.

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7 January 2021

RAF protein-serine/threonine kinases: structure and regulation

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7 January 2021

Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma

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7 January 2021

Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein

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7 January 2021

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

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7 January 2021

TopHat-Fusion: an algorithm for discovery of novel fusion transcripts

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7 January 2021

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

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7 January 2021

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

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7 January 2021

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

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7 January 2021

Identification of fusion genes in breast cancer by paired-end RNA-sequencing

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7 January 2021

Fast and accurate short read alignment with Burrows-Wheeler transform

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7 January 2021

VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing

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7 January 2021

MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a

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7 January 2021

Identifiers

DOI

10.1038/NCOMMS7087

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25608663%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

31 May 2020

ADS bibcode

2015NatCo...6.6087S

0 references

0 references

1 reference