EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR. (Q38875512)

7 September 2017

EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR. (English)

1 reference

7 September 2017

Christopher M Furcht

1

1 reference

PubMed ID

25969544

7 September 2017

Janine M Buonato

series ordinal

2

1 reference

PubMed ID

25969544

7 September 2017

Matthew J Lazzara

series ordinal

3

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7 September 2017

12 May 2015

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7 September 2017

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7 September 2017

8

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7 September 2017

376

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7 September 2017

ra46

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Perspective: Dynamics of receptor tyrosine kinase signaling complexes

7 September 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Computational analysis of the regulation of EGFR by protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

The "Gab" in signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Structure-based kinetic models of modular signaling protein function: focus on Shp2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Signal characteristics of G protein-transactivated EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Src family tyrosine kinases and growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

The diabetes susceptibility gene Clec16a regulates mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Capture of the small GTPase Rab5 by GDI: regulation by p38 MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Myristoylation and membrane binding regulate c-Src stability and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Src phosphorylates Grb2-associated binder 1 upon hepatocyte growth factor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Microtubules are stabilized in confluent epithelial cells but not in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Size and shape of protein molecules at the nanometer level determined by sedimentation, gel filtration, and electron microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

A structure-based model for ligand binding and dimerization of EGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Rate constants for binding, dissociation, and internalization of EGF: effect of receptor occupancy and ligand concentration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Cells die with increased cytosolic ATP during apoptosis: a bioluminescence study with intracellular luciferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: distribution of homo- and heterodimers depends on relative HER2 levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Ligand regulates epidermal growth factor receptor kinase specificity: activation increases preference for GAB1 and SHC versus autophosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

Systems Biology Toolbox for MATLAB: a computational platform for research in systems biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005697

10.1126/SCISIGNAL.2005697

21 January 2018

Identifiers

DOI

1 reference

7 September 2017

1 reference

PubMed ID

25969544