Methods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia (Q38871432)

7 September 2017

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title

Methods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia (English)

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7 September 2017

3

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7 September 2017

David Robert Grimes

2

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Alan McIntyre

object named as

Alan McIntyre

series ordinal

4

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author name string

Russell Leek

series ordinal

1

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PubMed ID

27325267

7 September 2017

language of work or name

English

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publication date

1 January 2016

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Advances in Experimental Medicine and Biology

7 September 2017

30

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based on heuristic

inferred from page(s)

published in

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7 September 2017

899

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7 September 2017

167-196

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Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.

7 September 2017

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-26666-4_10

Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology

21 January 2018

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Hypoxia--a key regulatory factor in tumour growth

21 January 2018

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Molecular aspects of cancer cell resistance to chemotherapy

21 January 2018

1 reference

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Critical role of aberrant angiogenesis in the development of tumor hypoxia and associated radioresistance

21 January 2018

1 reference

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Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality

21 January 2018

1 reference

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Multicellular tumor spheroids: an underestimated tool is catching up again.

21 January 2018

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Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy

21 January 2018

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Drug penetration in solid tumours

21 January 2018

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Macrophages promote angiogenesis in human breast tumour spheroids in vivo.

21 January 2018

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In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment.

21 January 2018

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Modeling colon adenocarcinomas in vitro a 3D co-culture system induces cancer-relevant pathways upon tumor cell and stromal fibroblast interaction

21 January 2018

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Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.

21 January 2018

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The Microenvironment of Cervical Carcinoma Xenografts: Associations with Lymph Node Metastasis and Its Assessment by DCE-MRI.

21 January 2018

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Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells

21 January 2018

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Rapid generation of single-tumor spheroids for high-throughput cell function and toxicity analysis

21 January 2018

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Spheroid culture as a tool for creating 3D complex tissues

21 January 2018

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The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway

21 January 2018

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Experimental anti-tumor therapy in 3-D: spheroids--old hat or new challenge?

21 January 2018

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Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

21 January 2018

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384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids

21 January 2018

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Dynamics of the self-assembly of complex cellular aggregates on micromolded nonadhesive hydrogels.

21 January 2018

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Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids

21 January 2018

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Efficient formation of uniform-sized embryoid bodies using a compartmentalized microchannel device

21 January 2018

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Microfluidic self-assembly of tumor spheroids for anticancer drug discovery

21 January 2018

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A multicellular spheroid array to realize spheroid formation, culture, and viability assay on a chip.

21 January 2018

1 reference

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The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation

21 January 2018

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High-throughput screening with nanoimprinting 3D culture for efficient drug development by mimicking the tumor environment

21 January 2018

1 reference

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Response to BCNU of spheroids grown from mixtures of drug-sensitive and drug-resistant cells.

21 January 2018

1 reference

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Cell-cell interactions in spheroids maintained in suspension.

21 January 2018

1 reference

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Brave little world: spheroids as an in vitro model to study tumor-immune-cell interactions

21 January 2018

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Hanging-drop multicellular spheroids as a model of tumour angiogenesis

21 January 2018

1 reference

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Regulation of the invasion suppressor function of the cadherin/catenin complex

21 January 2018

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A heterologous 3-D coculture model of breast tumor cells and fibroblasts to study tumor-associated fibroblast differentiation.

21 January 2018

1 reference

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Multiplexing spheroid volume, resazurin and acid phosphatase viability assays for high-throughput screening of tumour spheroids and stem cell neurospheres

21 January 2018

1 reference

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Effect of single-walled carbon nanotubes on tumor cells viability and formation of multicellular tumor spheroids

21 January 2018

1 reference

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Spheroid-based drug screen: considerations and practical approach

21 January 2018

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Development of multicellular tumor spheroid (MCTS) culture from breast cancer cell and a high throughput screening method using the MTT assay

21 January 2018

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

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A reliable tool to determine cell viability in complex 3-d culture: the acid phosphatase assay

21 January 2018

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Tumor Spheroids as an in vitro model for determining the therapeutic response to proton beam radiotherapy and thermally sensitive nanocarriers

21 January 2018

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Targeted radiotherapy of multicell neuroblastoma spheroids with high specific activity [125I]meta-iodobenzylguanidine

21 January 2018

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3D models of epithelial-mesenchymal transition in breast cancer metastasis: high-throughput screening assay development, validation, and pilot screen

21 January 2018

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Biosensor-expressing spheroid cultures for imaging of drug-induced effects in three dimensions.

21 January 2018

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3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions.

21 January 2018

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The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths

21 January 2018

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Imaging of neurosphere oxygenation with phosphorescent probes.

21 January 2018

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Phosphorescent light-emitting iridium complexes serve as a hypoxia-sensing probe for tumor imaging in living animals

21 January 2018

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Acquired multicellular-mediated resistance to alkylating agents in cancer

21 January 2018

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Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids

21 January 2018

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A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells.

21 January 2018

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Expression of carbonic anhydrase 9 is a novel prognostic marker in resectable hepatocellular carcinoma

21 January 2018

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Effect of pazopanib on tumor microenvironment and liposome delivery

21 January 2018

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Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours

21 January 2018

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

21 January 2018

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The Ki-67 protein: from the known and the unknown

21 January 2018

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Immunohistochemical detection of cell growth fraction in formalin-fixed and paraffin-embedded murine tissue

21 January 2018

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Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3.

21 January 2018

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3D tumour spheroids as a model to assess the suitability of [18F]FDG-PET as an early indicator of response to PI3K inhibition

21 January 2018

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A method for estimating the oxygen consumption rate in multicellular tumour spheroids

21 January 2018

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Analysis of growth of multicellular tumour spheroids by mathematical models

21 January 2018

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Role of optimal control theory in cancer chemotherapy

21 January 2018

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A mathematical model of the stress induced during avascular tumour growth.

21 January 2018

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Method for the determination of oxygen consumption rates and diffusion coefficients in multicellular spheroids

21 January 2018

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Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity

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Controlled gene expression in primary Lgr5 organoid cultures

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Generation of multicellular tumor spheroids by the hanging-drop method

31 March 2020

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Tumour-cell-endothelial interactions: free radicals are mediators of melanoma-induced endothelial cell damage

31 March 2020

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Cell culture: biology's new dimension

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The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy

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10.1007/978-3-319-26666-4_10

31 March 2020

Identifiers

DOI

1 reference

7 September 2017

1 reference

PubMed ID

27325267