Simple synthetic protein scaffolds can create adjustable artificial MAPK circuits in yeast and mammalian cells (Q38858396)

7 September 2017

Simple synthetic protein scaffolds can create adjustable artificial MAPK circuits in yeast and mammalian cells (English)

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7 September 2017

Jihoon Ryu

1

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7 September 2017

Sang-Hyun Park

series ordinal

2

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7 September 2017

language of work or name

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30 June 2015

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7 September 2017

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7 September 2017

8

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7 September 2017

383

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7 September 2017

ra66

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A synthetic oscillatory network of transcriptional regulators

7 September 2017

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Genetic programs constructed from layered logic gates in single cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Signaling through scaffold, anchoring, and adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Conformational Control of the Ste5 Scaffold Protein Insulates Against MAP Kinase Misactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Scaffolds: interaction platforms for cellular signalling circuits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Designing customized cell signalling circuits

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Reassembly of JIP1 scaffold complex in JNK MAP kinase pathway using heterologous protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Synthetic protein scaffolds provide modular control over metabolic flux.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Building signaling complexes at the membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Exploitation of latent allostery enables the evolution of new modes of MAP kinase regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Tunable signal processing in synthetic MAP kinase cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Energetic determinants of internal motif recognition by PDZ domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

The carboxy-terminal segment of the yeast alpha-factor receptor is a regulatory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Scaffold proteins: hubs for controlling the flow of cellular information

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Spatiotemporal control of cell signalling using a light-switchable protein interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

The assembly of a GTPase–kinase signalling complex by a bacterial catalytic scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Membrane recruitment of scaffold proteins drives specific signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Signal transduction: hanging on a scaffold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Engineering robust control of two-component system phosphotransfer using modular scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

A dimerization-dependent mechanism drives RAF catalytic activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Scaffold proteins in MAP kinase signaling: more than simple passive activating platforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Mutagenesis and selection of PDZ domains that bind new protein targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Assay of yeast mating reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

A Membrane Binding Domain in the Ste5 Scaffold Synergizes with Gβγ Binding to Control Localization and Signaling in Pheromone Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3397

10.1126/SCISIGNAL.AAB3397

21 January 2018

Identifiers

DOI

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release_4nt5xgaiofegtlprs2mznohjeu

7 September 2017

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https://api.fatcat.wiki/v0/release/4nt5xgaiofegtlprs2mznohjeu

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24 November 2022

based on heuristic

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