Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain (Q24554484)

The Pfam protein families database

GOA release 2020-03-11

author name string

Lindsay S Garrenton

series ordinal

1

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Susan L Young

series ordinal

2

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Jeremy Thorner

series ordinal

3

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language of work or name

English

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publication date

15 July 2006

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published in

Genes & Development

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volume

20

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issue

14

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page(s)

1946-58

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1522084

Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway

24 March 2017

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Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

24 March 2017

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24 March 2017

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Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains

24 March 2017

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Site-specific regulation of the GEF Cdc24p by the scaffold protein Far1p during yeast mating.

24 March 2017

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Cdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20.

24 March 2017

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The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating

24 March 2017

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Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

24 March 2017

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The G beta gamma complex of the yeast pheromone response pathway. Subcellular fractionation and protein-protein interactions

24 March 2017

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Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

24 March 2017

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Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.

24 March 2017

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24 March 2017

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7 April 2017

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COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes

7 April 2017

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Control of cell polarity in response to intra- and extracellular signals in budding yeast.

7 April 2017

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The nucleotide exchange factor Cdc24p may be regulated by auto-inhibition.

27 September 2017

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Nuclear export and plasma membrane recruitment of the Ste5 scaffold are coordinated with oligomerization and association with signal transduction components

27 September 2017

1 reference

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Improving the prediction of protein secondary structure in three and eight classes using recurrent neural networks and profiles.

27 September 2017

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The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate

27 September 2017

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27 September 2017

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Location, location, location: membrane targeting directed by PX domains

27 September 2017

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Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects

27 September 2017

1 reference

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Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the Ste5 scaffold protein

27 September 2017

1 reference

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Dual lipid modification of the yeast ggamma subunit Ste18p determines membrane localization of Gbetagamma

27 September 2017

1 reference

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Mutational analysis of STE5 in the yeast Saccharomyces cerevisiae: application of a differential interaction trap assay for examining protein-protein interactions.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1522084

Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1522084

The SH3-domain protein Bem1 coordinates mitogen-activated protein kinase cascade activation with cell cycle control in Saccharomyces cerevisiae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1522084

Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1522084

Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1522084

Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1522084

Cdc24 regulates nuclear shuttling and recruitment of the Ste5 scaffold to a heterotrimeric G protein in Saccharomyces cerevisiae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1522084

Functional binding between Gbeta and the LIM domain of Ste5 is required to activate the MEKK Ste11.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1522084

Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling

30 May 2018

1 reference

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The dimerization property of glutathione S-transferase partially reactivates Bcr-Abl lacking the oligomerization domain.

30 May 2018

1 reference

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Assay of yeast mating reaction

30 May 2018

1 reference

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Pheromone-induced phosphorylation of a G protein beta subunit in S. cerevisiae is associated with an adaptive response to mating pheromone

30 May 2018

1 reference

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A Membrane Binding Domain in the Ste5 Scaffold Synergizes with Gβγ Binding to Control Localization and Signaling in Pheromone Response

30 May 2018

1 reference

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Pheromone signaling mechanisms in yeast: a prototypical sex machine

28 November 2018

1 reference

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A simple and fast secondary structure prediction method using hidden neural networks.

28 November 2018

1 reference

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The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1522084

Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1522084

Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin

28 November 2018

1 reference

12 December 2020

Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade

1 reference

12 December 2020

Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo

1 reference

12 December 2020

Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein

1 reference

12 December 2020

Characterization of protein prenylation in Saccharomyces cerevisiae

1 reference

12 December 2020