Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling (Q38836365)

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scientific article published on 10 September 2015

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English	Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling	scientific article published on 10 September 2015

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scholarly article

1 reference

Europe PubMed Central

6 September 2017

Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling (English)

1 reference

Europe PubMed Central

6 September 2017

1 reference

based on heuristic

inferred from title

author name string

Bo Xu

1

1 reference

Europe PubMed Central

6 September 2017

Chuanwu Jiang

2

1 reference

Europe PubMed Central

6 September 2017

Hongxing Han

3

1 reference

Europe PubMed Central

6 September 2017

Hong Liu

4

1 reference

Europe PubMed Central

6 September 2017

Ming Tang

5

1 reference

Europe PubMed Central

6 September 2017

Longxi Liu

6

1 reference

Europe PubMed Central

6 September 2017

Wenyan Ji

7

1 reference

Europe PubMed Central

6 September 2017

Xuechao Lu

8

1 reference

Europe PubMed Central

6 September 2017

Xiuli Yang

9

1 reference

Europe PubMed Central

6 September 2017

Yunxu Zhang

10

1 reference

Europe PubMed Central

6 September 2017

Yongji Liu

11

1 reference

Europe PubMed Central

6 September 2017

publication date

10 September 2015

1 reference

Europe PubMed Central

6 September 2017

Clinical and Experimental Pharmacology and Physiology

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Europe PubMed Central

6 September 2017

42

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Europe PubMed Central

6 September 2017

12

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Europe PubMed Central

6 September 2017

1296-1307

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Europe PubMed Central

6 September 2017

Malignant astrocytic glioma: genetics, biology, and paths to treatment

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High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

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Molecular advances of brain tumors in radiation oncology

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Chemotherapy and novel therapeutic approaches in malignant glioma

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Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells

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Epithelial-to-mesenchymal(-like) transition as a relevant molecular event in malignant gliomas

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Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo

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Co-expression of MMP-14 and MMP-19 predicts poor survival in human glioma.

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Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma

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Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction.

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Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion

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Structure of the EMMPRIN N-terminal domain 1: dimerization via beta-strand swapping

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Expression of HAb18G is associated with tumor progression and prognosis of breast carcinoma

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Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin β1 to modulate malignant properties of hepatoma cells

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Clinical impact of HAb18G/CD147 expression in esophageal squamous cell carcinoma

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CD147, MMP9 expression and clinical significance of basal-like breast cancer

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Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas.

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Inhibition of basigin expression in glioblastoma cell line via antisense RNA reduces tumor cell invasion and angiogenesis

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Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro

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21 January 2018

A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner

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Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent pathway.

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21 January 2018

Enhanced co-expression of beta-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner.

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Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro

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Icaritin causes sustained ERK1/2 activation and induces apoptosis in human endometrial cancer cells

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Anticancer effect of icaritin on human lung cancer cells through inducing S phase cell cycle arrest and apoptosis

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An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells

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Icaritin inhibits JAK/STAT3 signaling and growth of renal cell carcinoma

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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

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Icaritin Sensitizes Human Glioblastoma Cells to TRAIL-Induced Apoptosis

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Colorectal cancer

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Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin

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21 January 2018

The basics of epithelial-mesenchymal transition

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21 January 2018

HIF-1α expression correlates with cellular apoptosis, angiogenesis and clinical prognosis in rectal carcinoma

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21 January 2018

Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors.

1 reference

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21 January 2018

RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion

1 reference

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21 January 2018

HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-β signaling and is transcriptionally regulated by Slug

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shRNA-mediated EMMPRIN silencing inhibits human leukemic monocyte lymphoma U937 cell proliferation and increases chemosensitivity to adriamycin

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Intracellular Acidosis Promotes Mitochondrial Apoptosis Pathway: Role of EMMPRIN Down-regulation via Specific Single-chain Fv Intrabody

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Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147.

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HAb18G/CD147 inhibits starvation-induced autophagy in human hepatoma cell SMMC7721 with an involvement of Beclin 1 down-regulation

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Overexpression of CD147 in ovarian cancer is initiated by the hypoxic microenvironment

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EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

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Gain of HIF-1α under normoxia in cancer mediates immune adaptation through the AKT/ERK and VEGFA axes

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EMMPRIN promotes angiogenesis, proliferation, invasion and resistance to sunitinib in renal cell carcinoma, and its level predicts patient outcome

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CD147 overexpression allows an accurate discrimination of bladder cancer patients’ prognosis

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10.1111/1440-1681.12488

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Europe PubMed Central

6 September 2017

release_ayqnisfgdrh3pjbqfvrneuta5q

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https://api.fatcat.wiki/v0/release/ayqnisfgdrh3pjbqfvrneuta5q

24 November 2022

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Europe PubMed Central

6 September 2017

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