An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells (Q34765600)

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English	An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells	scientific article

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scholarly article

1 reference

Europe PubMed Central

4 August 2017

An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells (English)

1 reference

Europe PubMed Central

4 August 2017

author name string

YuMing Guo

1

1 reference

Europe PubMed Central

4 August 2017

XinTian Zhang

2

1 reference

Europe PubMed Central

4 August 2017

Jun Meng

3

1 reference

Europe PubMed Central

4 August 2017

Zhao-Yi Wang

4

1 reference

Europe PubMed Central

4 August 2017

language of work or name

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publication date

1 March 2011

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Europe PubMed Central

4 August 2017

European Journal of Pharmacology

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Europe PubMed Central

4 August 2017

658

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Europe PubMed Central

4 August 2017

2-3

1 reference

Europe PubMed Central

4 August 2017

114-122

1 reference

Europe PubMed Central

4 August 2017

Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

1 reference

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7 July 2018

The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

1 reference

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Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.

1 reference

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Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition.

1 reference

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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

1 reference

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7 July 2018

Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy

1 reference

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Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells

1 reference

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A novel anticancer agent, icaritin, induced cell growth inhibition, G1 arrest and mitochondrial transmembrane potential drop in human prostate carcinoma PC-3 cells

1 reference

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Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer

1 reference

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Selective estrogen receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance

1 reference

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Mammary stem cells, self-renewal pathways, and carcinogenesis

1 reference

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Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells

1 reference

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ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

1 reference

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Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis

1 reference

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Map kinase signaling pathways and hematologic malignancies

1 reference

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Mechanisms of tamoxifen-induced apoptosis

1 reference

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7 July 2018

Mammalian MAP kinase signalling cascades

1 reference

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Cell cycle checkpoints and their inactivation in human cancer

1 reference

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Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures

1 reference

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Alteration of caspase-3 (CPP32/Yama/apopain) in wild-type MCF-7, breast cancer cells.

1 reference

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7 July 2018

Mitogen-activated protein kinase pathways

1 reference

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The role of proteases during apoptosis.

1 reference

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Cell cycle control and cancer

1 reference

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

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A New Anti-oestrogenic Agent in Late Breast Cancer: An Early Clinical Appraisal of ICI46474

1 reference

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7 July 2018

Endocrine therapy for advanced breast cancer: a review

1 reference

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Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1 reference

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Icaritin induces apoptosis of HepG2 cells via the JNK1 signaling pathway independent of the estrogen receptor

1 reference

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26 October 2018

A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner

1 reference

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Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro

1 reference

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Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent pathway.

1 reference

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Radiation resistance and stem-like cells in brain tumors.

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Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro

1 reference

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Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens

1 reference

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Reduction of c-Src activity by substituted 5,7-diphenyl-pyrrolo[2,3-d]-pyrimidines induces osteoclast apoptosis in vivo and in vitro. Involvement of ERK1/2 pathway

1 reference

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Transient and sustained ERK phosphorylation and nuclear translocation in growth control

1 reference

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Caspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes

1 reference

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Effects of tamoxifen on growth and apoptosis of estrogen-dependent and -independent human breast cancer cells

1 reference

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26 October 2018

Identifiers

10.1016/J.EJPHAR.2011.02.005

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

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