TSC2 regulates VEGF through mTOR-dependent and -independent pathways (Q44574474)

4 December 2017

TSC2 regulates VEGF through mTOR-dependent and -independent pathways (English)

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4 December 2017

5

William G Kaelin

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4 December 2017

James B Brugarolas

1

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4 December 2017

Francisca Vazquez

series ordinal

2

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4 December 2017

Archana Reddy

series ordinal

3

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4 December 2017

William R Sellers

series ordinal

4

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4 December 2017

1 August 2003

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4 December 2017

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4 December 2017

4

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4 December 2017

147-158

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4 December 2017

2

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Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.

4 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Molecular genetic advances in tuberous sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Atypical protein kinase Cs are the Ras effectors that mediate repression of myogenic satellite cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

VEGF and the quest for tumour angiogenesis factors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta -adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Definition of Two Angiogenic Pathways by Distinct alpha(v) Integrins

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Nitric oxide synthase inhibition attenuates the skeletal muscle VEGF mRNA response to exercise

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Regulation of translation initiation by FRAP/mTOR

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Molecular basis of the VHL hereditary cancer syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

von Hippel-Lindau disease

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Growth signaling: TSC takes its place.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Identification of the coding sequences responsible for Tsc2-mediated tumor suppression using a transgenic rat system

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Loss of tuberin, the tuberous-sclerosis-complex-2 gene product is associated with angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Identification of a conserved motif required for mTOR signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Molecular genetics of renal carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Stress-activated protein kinase/c-Jun N-terminal kinase (JNK) plays a part in endothelin-1-induced vascular endothelial growth factor synthesis in osteoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Cancer. Addiction to oncogenes--the Achilles heal of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Involvement of p38 MAP kinase in TGF-beta-stimulated VEGF synthesis in aortic smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900187-9

7 January 2021

10.1016/S1535-6108(03)00187-9

Identifiers

DOI

1 reference

release_h3am7y64ung6jfza7kgcdsovuy

4 December 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/h3am7y64ung6jfza7kgcdsovuy

24 November 2022

mapped directly with Wikidata item

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