Views on helper/cytotoxic lineage choice from a bottom-up approach (Q38810888)

6 September 2017

title

Views on helper/cytotoxic lineage choice from a bottom-up approach (English)

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6 September 2017

Ichiro Taniuchi

1

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6 September 2017

publication date

1 May 2016

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6 September 2017

published in

Immunological Reviews

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6 September 2017

volume

271

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6 September 2017

issue

1

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6 September 2017

page(s)

98-113

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Decision checkpoints in the thymus

6 September 2017

cites work

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The regulation of CD4 and CD8 coreceptor gene expression during T cell development

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Requirement for CD8 beta chain in positive selection of CD8-lineage T cells

21 January 2018

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Negative selection--clearing out the bad apples from the T-cell repertoire

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Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.

21 January 2018

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Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

21 January 2018

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Introduction: commitment to CD4 and CD8 lineages--stochastic or instructive?

21 January 2018

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In favor of the selective model of positive selection

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Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice

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T cell development: bottoms-up

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Transcriptional and epigenetic regulation of CD4/CD8 lineage choice.

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CD8 coreceptor extinction in signaled CD4(+)CD8(+) thymocytes: coordinate roles for both transcriptional and posttranscriptional regulatory mechanisms in developing thymocytes

21 January 2018

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New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

21 January 2018

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Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.

21 January 2018

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Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice

21 January 2018

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T cell-specific protein-DNA interactions occurring at the CD4 locus: identification of possible transcriptional control elements of the murine CD4 gene

21 January 2018

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Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene

21 January 2018

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A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

21 January 2018

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Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment.

21 January 2018

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Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation.

21 January 2018

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Heterochromatin and gene expression in Drosophila

21 January 2018

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A silencer-proximal intronic region is required for sustained CD4 expression in postselection thymocytes

21 January 2018

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Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells.

21 January 2018

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Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages

21 January 2018

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A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo

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Hierarchical interactions control CD4 gene expression during thymocyte development.

21 January 2018

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Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB

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B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.

21 January 2018

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Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression

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Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

21 January 2018

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RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes

21 January 2018

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Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

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Role of RUNX family members in transcriptional repression and gene silencing

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The evolutionary origin of the Runx/CBFbeta transcription factors--studies of the most basal metazoans

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Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulation

21 January 2018

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The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells.

21 January 2018

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Roles of VWRPY motif-mediated gene repression by Runx proteins during T-cell development

21 January 2018

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Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells.

21 January 2018

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An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells.

21 January 2018

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Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression.

21 January 2018

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Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development

21 January 2018

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Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

21 January 2018

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Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR

21 January 2018

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The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes

21 January 2018

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Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes

21 January 2018

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Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.

21 January 2018

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Cd8 enhancer E8I and Runx factors regulate CD8α expression in activated CD8+ T cells

21 January 2018

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Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

21 January 2018

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HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells

21 January 2018

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Regulation of lineage commitment distinct from positive selection.

21 January 2018

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The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.

21 January 2018

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Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

21 January 2018

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Role of the transcription factor Th-POK in CD4:CD8 lineage commitment

21 January 2018

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The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation

21 January 2018

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Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.

21 January 2018

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CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus.

21 January 2018

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Cutting edge: fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer

21 January 2018

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Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

21 January 2018

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Thymus lineage commitment: a single switch

21 January 2018

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Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus

21 January 2018

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Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate.

21 January 2018

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ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

21 January 2018

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The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells

21 January 2018

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The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer

21 January 2018

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Transcriptional regulation in helper versus cytotoxic-lineage decision

21 January 2018

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Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells

21 January 2018

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Development of all CD4 T lineages requires nuclear factor TOX

21 January 2018

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The many roles of TOX in the immune system

21 January 2018

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The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor

21 January 2018

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TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells

21 January 2018

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Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation.

21 January 2018

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Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes

21 January 2018

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Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation

21 January 2018

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Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

21 January 2018

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Ets-1 maintains IL-7 receptor expression in peripheral T cells

21 January 2018

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The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus

21 January 2018

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Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus

21 January 2018

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Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

21 January 2018

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MAZR and Runx Factors Synergistically Repress ThPOK during CD8+ T Cell Lineage Development.

21 January 2018

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Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes

21 January 2018

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An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b

21 January 2018

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An essential developmental checkpoint for production of the T cell lineage.

21 January 2018

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Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion

21 January 2018

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The multifaceted roles of Bcl11b in thymic and peripheral T cells: impact on immune diseases

21 January 2018

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Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells

21 January 2018

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BCL11B is required for positive selection and survival of double-positive thymocytes

21 January 2018

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Kinetic analysis of BCL11B multisite phosphorylation-dephosphorylation and coupled sumoylation in primary thymocytes by multiple reaction monitoring mass spectroscopy

21 January 2018

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Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

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Functional and mechanistic diversity of distal transcription enhancers

21 January 2018

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C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization

21 January 2018

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The Biology of Hematopoietic Stem Cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12401

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6 September 2017

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