Review: The lord of the rings: Structure and mechanism of the sliding clamp loader (Q38751208)

6 September 2017

Review: The lord of the rings: Structure and mechanism of the sliding clamp loader (English)

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6 September 2017

Brian A Kelch

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6 September 2017

26 February 2016

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6 September 2017

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6 September 2017

105

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6 September 2017

532-546

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6 September 2017

8

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Clamp loaders and replication initiation

6 September 2017

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Single-molecule analysis reveals that the lagging strand increases replisome processivity but slows replication fork progression

21 January 2018

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Characterization of a triple DNA polymerase replisome.

21 January 2018

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Molecular mechanism of PCNA-dependent base excision repair

21 January 2018

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Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis

21 January 2018

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Nuclear dynamics of PCNA in DNA replication and repair

21 January 2018

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PCNA directs type 2 RNase H activity on DNA replication and repair substrates

21 January 2018

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Inhibition of homologous recombination by the PCNA-interacting protein PARI

21 January 2018

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The Role of PCNA Posttranslational Modifications in Translesion Synthesis

21 January 2018

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Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation

21 January 2018

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Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin

21 January 2018

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A proposal: Evolution of PCNA's role as a marker of newly replicated DNA

21 January 2018

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Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth.

21 January 2018

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Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth

21 January 2018

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Targeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells

21 January 2018

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PCNA on the crossroad of cancer

21 January 2018

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Hypomorphic PCNA mutation underlies a human DNA repair disorder.

21 January 2018

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Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clamp

21 January 2018

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Structure of a Sliding Clamp on DNA

21 January 2018

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Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

21 January 2018

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Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA

21 January 2018

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Structure of PCNA fromDrosophila melanogaster

21 January 2018

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Crystal structure of an archaeal DNA sliding clamp: proliferating cell nuclear antigen from Pyrococcus furiosus

21 January 2018

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Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage

21 January 2018

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PCNA, the maestro of the replication fork

21 January 2018

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The carboxyl terminus of the bacteriophage T4 DNA polymerase is required for holoenzyme complex formation

21 January 2018

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A molecular switch in a replication machine defined by an internal competition for protein rings

21 January 2018

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Sequence analysis of the AAA protein family

21 January 2018

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AAA+ proteins: have engine, will work

21 January 2018

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Evolution and classification of P-loop kinases and related proteins

21 January 2018

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Opening of the clamp: an intimate view of an ATP-driven biological machine.

21 January 2018

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Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III

21 January 2018

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Motors and switches: AAA+ machines within the replisome.

21 January 2018

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Ordered ATP hydrolysis in the gamma complex clamp loader AAA+ machine.

21 January 2018

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Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding

21 January 2018

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Clamp loader ATPases and the evolution of DNA replication machinery

21 January 2018

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The ATP sites of AAA+ clamp loaders work together as a switch to assemble clamps on DNA

21 January 2018

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Origin remodeling and opening in bacteria rely on distinct assembly states of the DnaA initiator

21 January 2018

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DNA stretching by bacterial initiators promotes replication origin opening

21 January 2018

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ATP binding to the Escherichia coli clamp loader powers opening of the ring-shaped clamp of DNA polymerase III holoenzyme

21 January 2018

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The internal workings of a DNA polymerase clamp-loading machine

21 January 2018

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Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III

21 January 2018

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Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex

21 January 2018

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DNA polymerase clamp loaders and DNA recognition

21 January 2018

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Open clamp structure in the clamp-loading complex visualized by electron microscopic image analysis

21 January 2018

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The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex

21 January 2018

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How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

21 January 2018

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Evolutionary relationships and structural mechanisms of AAA+ proteins

21 January 2018

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Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III

21 January 2018

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Solution study of the Escherichia coli DNA polymerase III clamp loader reveals the location of the dynamic ψχ heterodimer

21 January 2018

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Mechanism of DNA elongation catalyzed by Escherichia coli DNA polymerase III, dnaZ protein, and DNA elongation factors I and III

21 January 2018

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Complementation of one RecA protein point mutation by another. Evidence for trans catalysis of ATP hydrolysis.

21 January 2018

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Running in Reverse: The Structural Basis for Translocation Polarity in Hexameric Helicases

21 January 2018

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Structure and mechanism of the ATPase that powers viral genome packaging

21 January 2018

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Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

21 January 2018

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ATP utilization by yeast replication factor C. II. Multiple stepwise ATP binding events are required to load proliferating cell nuclear antigen onto primed DNA.

21 January 2018

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Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex

21 January 2018

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Multiple ATP binding is required to stabilize the "activated" (clamp open) clamp loader of the T4 DNA replication complex

21 January 2018

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Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit

21 January 2018

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A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme

21 January 2018

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ATP-dependent structural change of the eukaryotic clamp-loader protein, replication factor C.

21 January 2018

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ATP utilization by yeast replication factor C. I. ATP-mediated interaction with DNA and with proliferating cell nuclear antigen

21 January 2018

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Division of labor--sequential ATP hydrolysis drives assembly of a DNA polymerase sliding clamp around DNA.

21 January 2018

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Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex

21 January 2018

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A slow ATP-induced conformational change limits the rate of DNA binding but not the rate of beta clamp binding by the escherichia coli gamma complex clamp loader.

21 January 2018

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Mechanism of ATP-driven PCNA clamp loading by S. cerevisiae RFC.

21 January 2018

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Replication factor C is a more effective proliferating cell nuclear antigen (PCNA) opener than the checkpoint clamp loader, Rad24-RFC.

21 January 2018

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The Escherichia coli Clamp Loader Can Actively Pry Open the -Sliding Clamp

21 January 2018

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Interplay of clamp loader subunits in opening the beta sliding clamp of Escherichia coli DNA polymerase III holoenzyme

21 January 2018

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Mechanism of beta clamp opening by the delta subunit of Escherichia coli DNA polymerase III holoenzyme.

21 January 2018

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Intricacies in ATP-dependent clamp loading: variations across replication systems

21 January 2018

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Examination of the role of the clamp-loader and ATP hydrolysis in the formation of the bacteriophage T4 polymerase holoenzyme

21 January 2018

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Intrinsic stability and oligomerization dynamics of DNA processivity clamps

21 January 2018

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Clamp loading, unloading and intrinsic stability of the PCNA, beta and gp45 sliding clamps of human, E. coli and T4 replicases

21 January 2018

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Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus

21 January 2018

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Sliding clamp of the bacteriophage T4 polymerase has open and closed subunit interfaces in solution

21 January 2018

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Tracking sliding clamp opening and closing during bacteriophage T4 DNA polymerase holoenzyme assembly.

21 January 2018

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Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer

21 January 2018

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On the solution structure of the T4 sliding clamp (gp45).

21 January 2018

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A general model for nucleic acid helicases and their "coupling" within macromolecular machines

21 January 2018

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Assembly of a functional replication complex without ATP hydrolysis: a direct interaction of bacteriophage T4 gp45 with T4 DNA polymerase

21 January 2018

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An alternative clamp loading pathway via the T4 clamp loader gp44/62-DNA complex.

21 January 2018

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ATP binding and hydrolysis-driven rate-determining events in the RFC-catalyzed PCNA clamp loading reaction

21 January 2018

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Recognition of the ring-opened state of proliferating cell nuclear antigen by replication factor C promotes eukaryotic clamp-loading.

21 January 2018

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The Elg1 replication factor C-like complex functions in PCNA unloading during DNA replication.

21 January 2018

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Is PCNA unloading the central function of the Elg1/ATAD5 replication factor C-like complex?

21 January 2018

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Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation.

21 January 2018

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Clamp loaders and sliding clamps

21 January 2018

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The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer

21 January 2018

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Dynamics of loading the beta sliding clamp of DNA polymerase III onto DNA.

21 January 2018

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On the specificity of interaction between the Saccharomyces cerevisiae clamp loader replication factor C and primed DNA templates during DNA replication

21 January 2018

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Analysis of the role of PCNA-DNA contacts during clamp loading

21 January 2018

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Impact of individual proliferating cell nuclear antigen-DNA contacts on clamp loading and function on DNA.

21 January 2018

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Mechanism of loading the Escherichia coli DNA polymerase III beta sliding clamp on DNA. Bona fide primer/templates preferentially trigger the gamma complex to hydrolyze ATP and load the clamp

21 January 2018

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How does GAP catalyze the GTPase reaction of Ras? A computer simulation study

21 January 2018

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Hypothesis: bacterial clamp loader ATPase activation through DNA-dependent repositioning of the catalytic base and of a trans-acting catalytic threonine

21 January 2018

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Structure of the recA protein–ADP complex

21 January 2018

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Crystal structure of a DExx box DNA helicase

21 January 2018

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Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp: II. Uncoupling the beta and DNA binding activities of the gamma complex

21 January 2018

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ATP utilization by yeast replication factor C. III. The ATP-binding domains of Rfc2, Rfc3, and Rfc4 are essential for DNA recognition and clamp loading

21 January 2018

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A central swivel point in the RFC clamp loader controls PCNA opening and loading on DNA

21 January 2018

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ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins

21 January 2018

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ATP utilization by yeast replication factor C. IV. RFC ATP-binding mutants show defects in DNA replication, DNA repair, and checkpoint regulation

21 January 2018

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Distinct roles for ATP binding and hydrolysis at individual subunits of an archaeal clamp loader

21 January 2018

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The β sliding clamp closes around DNA prior to release by the Escherichia coli clamp loader γ complex

21 January 2018

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Kinetic analysis of PCNA clamp binding and release in the clamp loading reaction catalyzed by Saccharomyces cerevisiae replication factor C.

21 January 2018

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Stepwise assembly of the human replicative polymerase holoenzyme.

21 January 2018

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The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation

21 January 2018

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Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling

21 January 2018

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Crystal and solution structures of an HslUV protease-chaperone complex

21 January 2018

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Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism

21 January 2018

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Nucleotide-dependent domain motions within rings of the RecA/AAA(+) superfamily

21 January 2018

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Mechanism of DNA translocation in a replicative hexameric helicase

21 January 2018

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Mechanism of force generation of a viral DNA packaging motor

21 January 2018

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Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex

21 January 2018

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Structural basis of DNA replication origin recognition by an ORC protein

21 January 2018

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Structural Synergy and Molecular Crosstalk between Bacterial Helicase Loaders and Replication Initiators

21 January 2018

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Crystal structure of the eukaryotic origin recognition complex

21 January 2018

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An Atypical AAA+ ATPase Assembly Controls Efficient Transposition through DNA Remodeling and Transposase Recruitment

21 January 2018

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On helicases and other motor proteins

21 January 2018

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AAA+ proteases: ATP-fueled machines of protein destruction

21 January 2018

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Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures

21 January 2018

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Structural insights into RNA-dependent ring closure and ATPase activation by the Rho termination factor

21 January 2018

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Rho-dependent termination and ATPases in transcript termination

21 January 2018

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Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine

21 January 2018

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The gamma subunit of DNA polymerase III holoenzyme of Escherichia coli is produced by ribosomal frameshifting

21 January 2018

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Translational frameshifting generates the gamma subunit of DNA polymerase III holoenzyme

21 January 2018

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Programmed ribosomal frameshifting generates the Escherichia coli DNA polymerase III gamma subunit from within the tau subunit reading frame

21 January 2018

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The PCNA-RFC families of DNA clamps and clamp loaders

21 January 2018

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Elg1 forms an alternative RFC complex important for DNA replication and genome integrity

21 January 2018

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ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C

21 January 2018

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Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability

21 January 2018

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ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing

21 January 2018

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Replication factor C complexes play unique pro- and anti-establishment roles in sister chromatid cohesion

21 January 2018

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The ELG1 clamp loader plays a role in sister chromatid cohesion

21 January 2018

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Predisposition to cancer caused by genetic and functional defects of mammalian Atad5

21 January 2018

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ATAD5 deficiency decreases B cell division and Igh recombination

21 January 2018

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Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA.

21 January 2018

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ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin

21 January 2018

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Alternative replication factor C protein, Elg1, maintains chromosome stability by regulating PCNA levels on chromatin

21 January 2018

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Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall

21 January 2018

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Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae

21 January 2018

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Establishment of sister chromatid cohesion at the S. cerevisiae replication fork

21 January 2018

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Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway

21 January 2018

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A DNA integrity network in the yeast Saccharomyces cerevisiae

21 January 2018

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Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response

21 January 2018

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Quantitative proteomic analysis of chromatin reveals that Ctf18 acts in the DNA replication checkpoint.

21 January 2018

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Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance

21 January 2018

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The Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles

21 January 2018

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Mechanical link between cohesion establishment and DNA replication: Ctf7p/Eco1p, a cohesion establishment factor, associates with three different replication factor C complexes

21 January 2018

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PCNA controls establishment of sister chromatid cohesion during S phase

21 January 2018

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A molecular determinant for the establishment of sister chromatid cohesion

21 January 2018

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Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion

21 January 2018

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Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast

21 January 2018

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Cohesin acetylation speeds the replication fork

21 January 2018

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Replication protein A-directed unloading of PCNA by the Ctf18 cohesion establishment complex

21 January 2018

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Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8

21 January 2018

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A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.

21 January 2018

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Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways

21 January 2018

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Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint

21 January 2018

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Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctions

21 January 2018

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Mechanisms and regulation of DNA end resection

21 January 2018

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Single-molecule studies of DNA replisome function

21 January 2018

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Single-molecule investigation of the T4 bacteriophage DNA polymerase holoenzyme: multiple pathways of holoenzyme formation

21 January 2018

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Probing DNA clamps with single-molecule force spectroscopy.

21 January 2018

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2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor

21 January 2018

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Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity

21 January 2018

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The Resolution Revolution

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIP.22827

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6 September 2017

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PubMed ID

26918303