Neurotrophin signaling in cancer stem cells (Q38736387)

6 September 2017

Neurotrophin signaling in cancer stem cells (English)

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6 September 2017

neoplastic stem cells

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Robert-Alain Toillon

3

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author name string

Valérie Chopin

series ordinal

1

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PubMed ID

26883804

6 September 2017

Chann Lagadec

series ordinal

2

1 reference

PubMed ID

26883804

6 September 2017

Xuefen Le Bourhis

series ordinal

4

1 reference

6 September 2017

17 February 2016

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Cellular and Molecular Life Sciences

6 September 2017

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6 September 2017

73

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6 September 2017

9

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6 September 2017

1859-1870

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https://scigraph.springernature.com/pub.10.1007/s00018-016-2156-7

6 September 2017

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cites work

Prospective identification of tumorigenic breast cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Identification of human brain tumour initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

A restricted cell population propagates glioblastoma growth after chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Defining the mode of tumour growth by clonal analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Stem cell gene expression programs influence clinical outcome in human leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

A mesenchymal glioma stem cell profile is related to clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Migratory gene expression signature predicts poor patient outcome: are cancer stem cells to blame?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Understanding cancer stem cell heterogeneity and plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Neurotrophins and their receptors: a convergence point for many signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Structural model for p75(NTR)-TrkA intracellular domain interaction: a combined FRET and bioinformatics study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The yin and yang of neurotrophin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Expression of nerve growth factor receptors is correlated with progression and prognosis of human pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Expression of nerve growth factor and tyrosine kinase receptor A and correlation with perineural invasion in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Nerve growth factor and tyrosine kinase A receptor in oral squamous cell carcinoma: is there an association with perineural invasion?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Nerve Growth Factor Signals as Possible Pathogenic Biomarkers for Perineural Invasion in Adenoid Cystic Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Altered expression of metastasis-associated and regulatory molecules in effusions from breast cancer patients: a novel model for tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

TrkA overexpression enhances growth and metastasis of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Ku86 is important for TrkA overexpression-induced breast cancer cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Nerve growth factor as an angiogenic factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The effect of P75 on Trk receptors in neuroblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Trks are novel oncogenes involved in the induction of neovascularization, tumor progression, and nodal metastasis in oral squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Brain-derived neurotrophic factor/tropomyosin-related kinase B pathway in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Brain-derived neurotrophic factor (BDNF)-induced tropomyosin-related kinase B (Trk B) signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Expression of the neurotrophin receptor TrkB is associated with unfavorable outcome in Wilms' tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Activation of trk-A but not trk-B signal transduction pathway inhibits growth of neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Suppression of choriocarcinoma invasion and metastasis following blockade of BDNF/TrkB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

p75 neurotrophin receptor suppresses the proliferation of human gastric cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The p75(NTR) tumor suppressor induces caspase-mediated apoptosis in bladder tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The p75(NTR) tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Overexpression of p75(NTR) increases survival of breast cancer cells through p21(waf1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The p75 neurotrophin receptor is a central regulator of glioma invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Neurotrophins and their receptors stimulate melanoma cell proliferation and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Brain metastases in melanoma: roles of neurotrophins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Role of p75 neurotrophin receptor in stem cell biology: more than just a marker

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Inactivation of glycogen synthase kinase-3beta contributes to brain-derived neutrophic factor/TrkB-induced resistance to chemotherapy in neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Theraputic targeting of Trk supresses tumor proliferation and enhances cisplatin activity in HNSCC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The nerve growth factor receptor CD271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

TrkB is responsible for EMT transition in malignant pleural effusions derived cultures from adenocarcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Patterns of expression and function of the p75(NGFR) protein in pancreatic cancer cells and tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Altered expression and activation of the nerve growth factor receptors TrkA and p75 provide the first evidence of tumor progression to effusion in breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Extracellular cleavage of the p75 neurotrophin receptor is implicated in its pro-survival effect in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The TrkB+ cancer stem cells contribute to post-chemotherapy recurrence of triple-negative breast cancers in an orthotopic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

High TrkB expression levels are associated with poor prognosis and EMT induction in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Tropomyosin receptor kinases B and C are tumor progressive and metastatic marker in colorectal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

An intracellular domain fragment of the p75 neurotrophin receptor (p75(NTR)) enhances tropomyosin receptor kinase A (TrkA) receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Brain cancer stem cells display preferential sensitivity to Akt inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Neurotrophin-regulated signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The TrkAIII oncoprotein inhibits mitochondrial free radical ROS-induced death of SH-SY5Y neuroblastoma cells by augmenting SOD2 expression and activity at the mitochondria, within the context of a tumour stem cell-like phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Nerve growth factor and proNGF simultaneously promote symmetric self-renewal, quiescence, and epithelial to mesenchymal transition to enlarge the breast cancer stem cell compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Asymmetric and symmetric stem-cell divisions in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Sortilin is essential for proNGF-induced neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Key Roles of Hyaluronan and Its CD44 Receptor in the Stemness and Survival of Cancer Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Reprogramming of human somatic cells to pluripotency with defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Molecular mechanisms of epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Slug and Sox9 cooperatively determine the mammary stem cell state

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

A TrkB-STAT3-miR-204-5p regulatory circuitry controls proliferation and invasion of endometrial carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Upregulation of TrkB promotes epithelial-mesenchymal transition and anoikis resistance in endometrial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Targets of miR-200c mediate suppression of cell motility and anoikis resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Neurotrophin system activation in pleural effusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

The malignant pleural effusion as a model to investigate intratumoral heterogeneity in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Spheres derived from lung adenocarcinoma pleural effusions: molecular characterization and tumor engraftment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-016-2156-7

Nerve Growth Factor Cooperates with p185HER2in Activating Growth of Human Breast Carcinoma Cells

21 January 2018

1 reference

12 December 2020

Glioma invasion mediated by the p75 neurotrophin receptor (p75(NTR)/CD271) requires regulated interaction with PDLIM1.

1 reference

12 December 2020

Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues

1 reference

12 December 2020

Expression and activation of the nerve growth factor receptor TrkA in serous ovarian carcinoma

1 reference

12 December 2020

Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells.

1 reference

12 December 2020

Brain-derived neurotrophic factor protects neuroblastoma cells from vinblastine toxicity.

1 reference

12 December 2020

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo

1 reference

12 December 2020

Expression of nerve growth factor receptors and their prognostic value in human pancreatic cancer.

1 reference

12 December 2020

Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations.

1 reference

12 December 2020

CD133 expression defines a tumor initiating cell population in primary human ovarian cancer

1 reference

12 December 2020

Mature BDNF promotes the growth of glioma cells in vitro

1 reference

12 December 2020

Expression of the neurotrophin receptor TrkA down-regulates expression and function of angiogenic stimulators in SH-SY5Y neuroblastoma cells

1 reference

12 December 2020

Expression of brain-derived neurotrophic factor and p145TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells.

1 reference

12 December 2020

Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway.

1 reference

12 December 2020

Inverse relationship between trk expression and N-myc amplification in human neuroblastomas

1 reference

12 December 2020

Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors

1 reference

12 December 2020

Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse.

1 reference

12 December 2020

Tissue-specific alternative splicing generates two isoforms of the trkA receptor.

1 reference

12 December 2020

The activated nerve growth factor receptor p-TrkA is selectively expressed in advanced-stage ovarian carcinoma

1 reference

12 December 2020

p75(NGFR) immunostaining for the detection of perineural invasion by cutaneous squamous cell carcinoma

1 reference

12 December 2020

Nerve growth factor is a potential therapeutic target in breast cancer

1 reference

12 December 2020

10.1007/S00018-016-2156-7

Identifiers

DOI

1 reference

6 September 2017

1 reference

PubMed ID

26883804