Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome. (Q38716763)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

title

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

main subject

lymphoblastic leukemia

1 reference

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Matthew T Witkowski

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Yifang Hu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Oliver D Le Grice

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Cedric S Tremblay

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Tracy A Willson

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Martin A Horstmann

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Luisa Cimmino

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Monique L den Boer

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Ross A. Dickins

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

12

Iannis Aifantis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

author name string

Kathryn G Roberts

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Judith M Boer

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Mark D McKenzie

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Grace J Liu

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Margherita Ghisi

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Seth Frietze

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Charles G Mullighan

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

language of work or name

English

0 references

publication date

11 February 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

Journal of Experimental Medicine

2 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

volume

214

1 reference

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2 April 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

page(s)

773-791

1 reference

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describes a project that uses

2 April 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/5339666

based on heuristic

inferred from PubMed Central ID database lookup

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Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia

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limma powers differential expression analyses for RNA-sequencing and microarray studies

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Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia

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Ikaros deletions in BCR-ABL-negative childhood acute lymphoblastic leukemia are associated with a distinct gene expression signature but do not result in intrinsic chemoresistance

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Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

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Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

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23 June 2018

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Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals

23 June 2018

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Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros

23 June 2018

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Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.

23 June 2018

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Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia

23 June 2018

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IFITM3 restricts the morbidity and mortality associated with influenza

23 June 2018

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KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis

23 June 2018

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23 June 2018

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23 June 2018

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Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia

23 June 2018

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IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL.

23 June 2018

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23 June 2018

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23 June 2018

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23 June 2018

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IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report

23 June 2018

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Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute

23 June 2018

1 reference

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A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

23 June 2018

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Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia

23 June 2018

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Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

23 June 2018

1 reference

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Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia

23 June 2018

1 reference

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Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.

23 June 2018

1 reference

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Empirical array quality weights in the analysis of microarray data

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Early hematopoietic lineage restrictions directed by Ikaros.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Identification of the IFITM family as a new molecular marker in human colorectal tumors

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

IFITM/Mil/Fragilis Family Proteins IFITM1 and IFITM3 Play Distinct Roles in Mouse Primordial Germ Cell Homing and Repulsion

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

A role for Kaiso-p120ctn complexes in cancer?

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

A core function for p120-catenin in cadherin turnover

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

A novel role for p120 catenin in E-cadherin function

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Changes in gene expression profiles in developing B cells of murine bone marrow

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Defects in hemopoietic stem cell activity in Ikaros mutant mice

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Generation of lymphohematopoietic cells from embryonic stem cells in culture

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Acute leukaemia in bcr/abl transgenic mice

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Acute Lymphoblastic Leukemia in Children.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Stage-specific control of early B cell development by the transcription factor Ikaros.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Biclonal and biallelic deletions occur in 20% of B-ALL cases with IKZF1 mutations.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Vav promoter-tTA conditional transgene expression system for hematopoietic cells drives high level expression in developing B and T cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Use of within-array replicate spots for assessing differential expression in microarray experiments.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5339666

Cellular immunotherapy as a beacon of hope for hematological malignancies

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20160048

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20160048

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28190000

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28190000

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20160048

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28190000%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference