BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros (Q57734316)

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object named as

Ching-Hon Pui

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Michelle M Le Beau

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object named as

Michelle M. Le Beau

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James T Dalton

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object named as

James Dalton

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author name string

Charles G. Mullighan

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Christopher B. Miller

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Ina Radtke

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Letha A. Phillips

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Jing Ma

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Timothy P. Hughes

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Mary V. Relling

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Sheila A. Shurtleff

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James R. Downing

https://scigraph.springernature.com/pub.10.1038/nature06866

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language of work or name

English

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publication date

13 April 2008

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published in

Nature

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volume

453

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page(s)

110-114

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issue

7191

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exact match

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cites work

The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene

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The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins

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Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis.

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Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia

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Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies

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Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes.

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Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia

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Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia

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Detection of different Ikaros isoforms in human leukaemias using real-time quantitative polymerase chain reaction

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Expression of the Ikaros gene family in childhood acute lymphoblastic leukaemia

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Overexpression of dominant-negative Ikaros 6 protein is restricted to a subset of B common adult acute lymphoblastic leukemias that express high levels of the CD34 antigen

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BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells

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Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

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The Ikaros gene is required for the development of all lymphoid lineages

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A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

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Characterizing the cancer genome in lung adenocarcinoma

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Ikaros is critical for B cell differentiation and function.

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Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

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