Genomics in acute lymphoblastic leukaemia: insights and treatment implications (Q38381463)

2 September 2017

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title

Genomics in acute lymphoblastic leukaemia: insights and treatment implications (English)

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2 September 2017

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2

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2 September 2017

Kathryn G Roberts

1

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PubMed ID

25781572

2 September 2017

language of work or name

English

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publication date

17 March 2015

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Nature Reviews Clinical Oncology

2 September 2017

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2 September 2017

12

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2 September 2017

6

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2 September 2017

344-357

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Acute lymphoblastic leukaemia

2 September 2017

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Outcome of patients treated for relapsed or refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Adolescents and young adults with acute lymphoblastic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

JAK mutations in high-risk childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

CREBBP mutations in relapsed acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Genetic loss of SH2B3 in acute lymphoblastic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

21 January 2018

WT1 mutations in T-ALL

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

ETV6 mutations in early immature human T cell leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

PHF6 mutations in T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

The genomic landscape of hypodiploid acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Advances in understanding cancer genomes through second-generation sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Cancer genome sequencing: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Diagnostic clinical genome and exome sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Genome regulation by long noncoding RNAs.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Regulation of transcription by long noncoding RNAs

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

lincRNAs: genomics, evolution, and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Cytogenetics and molecular genetics of acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

High hyperdiploid childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Molecular pathogenesis of T-cell leukaemia and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Genomic characterization of childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Loss of chromosomes is the primary event in near-haploid and low-hypodiploid acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Functional heterogeneity of PAX5 chimeras reveals insight for leukemia development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Dominant-negative mechanism of leukemogenic PAX5 fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Stage-specific control of early B cell development by the transcription factor Ikaros.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

IKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

The JAK-STAT pathway at twenty

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Treating childhood acute lymphoblastic leukemia without cranial irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Tyrosine kinase inhibitor therapy induces remission in a patient with refractory EBF1-PDGFRB-positive acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Successful tyrosine kinase inhibitor therapy in a refractory B-cell precursor acute lymphoblastic leukemia with EBF1-PDGFRB fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

IKZF1 and CRLF2 gene alterations correlate with poor prognosis in Japanese BCR-ABL1-negative high-risk B-cell precursor acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Treatment outcome of CRLF2-rearranged childhood acute lymphoblastic leukaemia: a comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93%.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Intrachromosomal amplification of chromosome 21 is associated with inferior outcomes in children with acute lymphoblastic leukemia treated in contemporary standard-risk children's oncology group studies: a report from the children's oncology group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Risk-directed treatment intensification significantly reduces the risk of relapse among children and adolescents with acute lymphoblastic leukemia and intrachromosomal amplification of chromosome 21: a comparison of the MRC ALL97/99 and UKALL2003 tr

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

A new prognostic score for CLL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Methylation of the IL-12Rbeta2 gene as novel tumor escape mechanism for pediatric B-acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Promoter DNA methylation pattern identifies prognostic subgroups in childhood T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Progressive myoclonic ataxia associated with coeliac disease. The myoclonus is of cortical origin, but the pathology is in the cerebellum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Mutational heterogeneity in cancer and the search for new cancer-associated genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Mutational landscape and significance across 12 major cancer types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

The Cancer Genome Atlas Pan-Cancer analysis project

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Germline genomic variants associated with childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype

21 January 2018

1 reference

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Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Identification of TP53 as an acute lymphocytic leukemia susceptibility gene through exome sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Biology, risk stratification, and therapy of pediatric acute leukemias: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Minimal residual disease monitoring in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Impact of IKZF1 deletions on IKZF1 expression and outcome in Philadelphia chromosome negative childhood BCP-ALL. Reply to "incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Relapsed childhood acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Highly sensitive MRD tests for ALL based on the IKZF1 Δ3-6 microdeletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Screening for gene mutations: will identification of NT5C2 mutations help predict the chance of relapse in acute lymphoblastic leukemia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Analysis of TP53 mutations in relapsed childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Acute Lymphoblastic Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

High Expression Levels of theETS-Related Gene,ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Reassessment of the prognostic significance of hypodiploidy in pediatric patients with acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Cancer genomes: discerning drivers from passengers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2015.38

Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia

31 March 2020

1 reference

12 December 2020

Where do we stand in the treatment of relapsed acute lymphoblastic leukemia?

1 reference

12 December 2020

Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.

1 reference

12 December 2020

p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation.

1 reference

12 December 2020

Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia.

1 reference

12 December 2020

Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line

1 reference

12 December 2020

Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A.

1 reference

12 December 2020

10.1038/NRCLINONC.2015.38

Identifiers

DOI

1 reference

2 September 2017

1 reference

PubMed ID

25781572