Centrosomes and cancer: revisiting a long-standing relationship (Q38614245)

4 September 2017

Centrosomes and cancer: revisiting a long-standing relationship (English)

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4 September 2017

1

Pierre Gönczy

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language of work or name

English

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publication date

1 October 2015

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4 September 2017

Nature Reviews Cancer

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4 September 2017

15

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4 September 2017

11

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4 September 2017

639-652

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https://scigraph.springernature.com/pub.10.1038/nrc3995

4 September 2017

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cites work

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The mouse Mps1p-like kinase regulates centrosome duplication

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CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells

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Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

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Microsurgical removal of centrosomes blocks cell reproduction and centriole generation in BSC-1 cells

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31 March 2020

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Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization

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Timing of centrosome separation is important for accurate chromosome segregation

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USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis

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The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.

31 March 2020

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Asymmetric inheritance of mother versus daughter centrosome in stem cell division

31 March 2020

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Asymmetric centrosome inheritance maintains neural progenitors in the neocortex

31 March 2020

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Cnn dynamics drive centrosome size asymmetry to ensure daughter centriole retention in Drosophila neuroblasts

31 March 2020

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Drosophila neuroblasts retain the daughter centrosome.

31 March 2020

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A localized Wnt signal orients asymmetric stem cell division in vitro

31 March 2020

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How do cilia organize signalling cascades?

31 March 2020

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The primary cilium: a signalling centre during vertebrate development

31 March 2020

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31 March 2020

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Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling

31 March 2020

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

31 March 2020

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Dual and opposing roles of primary cilia in medulloblastoma development

31 March 2020

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Oncogene-like induction of cellular invasion from centrosome amplification

31 March 2020

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The diverse roles of Rac signaling in tumorigenesis

31 March 2020

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Centrosome function in cancer: guilty or innocent?

31 March 2020

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Causes and consequences of centrosome abnormalities in cancer

31 March 2020

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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer

31 March 2020

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Centrosome dynamics as a source of chromosomal instability

31 March 2020

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Centrioles, centrosomes, and cilia in health and disease

31 March 2020

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The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis

31 March 2020

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Deuterosome-mediated centriole biogenesis

31 March 2020

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Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation

31 March 2020

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RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity

31 March 2020

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Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres

31 March 2020

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Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity

31 March 2020

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Fate of microtubule-organizing centers during myogenesis in vitro

31 March 2020

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Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes

31 March 2020

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The arithmetic of centrosome biogenesis

31 March 2020

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GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

31 March 2020

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Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent

31 March 2020

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Polo-like kinase 4 inhibition: a strategy for cancer therapy?

31 March 2020

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The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4.

31 March 2020

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The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication.

31 March 2020

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Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation

31 March 2020

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Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy

31 March 2020

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Polyploidy and liver proliferation.

31 March 2020

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Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes

31 March 2020

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GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo

31 March 2020

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A census of human cancer genes

31 March 2020

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Discovery and saturation analysis of cancer genes across 21 tumour types

31 March 2020

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Pan-cancer patterns of somatic copy number alteration

31 March 2020

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Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase

31 March 2020

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SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing

31 March 2020

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Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells

31 March 2020

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Cyclin B2 and p53 control proper timing of centrosome separation

31 March 2020

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12 December 2020

Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas

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12 December 2020

The checkpoint control for anaphase onset does not monitor excess numbers of spindle poles or bipolar spindle symmetry.

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12 December 2020

Differences in the regulation of protein synthesis, cyclin B accumulation, and cellular growth in response to the inhibition of DNA synthesis in Chinese hamster ovary and HeLa S3 cells

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12 December 2020

Centrosome defects and genetic instability in malignant tumors

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12 December 2020

P53, cyclin-dependent kinase and abnormal amplification of centrosomes

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12 December 2020

Identifiers

DOI

10.1038/NRC3995

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PubMed ID

26493645

Dimensions Publication ID

4 September 2017

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1 reference

PubMed ID

26493645