Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. (Q34474551)

2 August 2017

Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. (English)

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2 August 2017

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11

Brian J Mitchell

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2 August 2017

15

Karen Oegema

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Yao Liang Wong

object named as

Yao Liang Wong

1

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author name string

John V Anzola

2

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2 August 2017

Robert L Davis

3

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2 August 2017

Michelle Yoon

4

1 reference

2 August 2017

Amir Motamedi

5

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2 August 2017

Ashley Kroll

6

1 reference

2 August 2017

Chanmee P Seo

7

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2 August 2017

Judy E Hsia

8

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2 August 2017

Sun K Kim

9

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2 August 2017

Jennifer W Mitchell

10

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2 August 2017

Arshad Desai

12

1 reference

2 August 2017

Timothy C Gahman

13

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2 August 2017

Andrew K Shiau

14

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2 August 2017

language of work or name

English

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publication date

30 April 2015

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2 August 2017

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2 August 2017

348

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2 August 2017

6239

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2 August 2017

1155-1160

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Stabilization of cartwheel-less centrioles for duplication requires CEP295-mediated centriole-to-centrosome conversion

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Cytokinesis failure triggers hippo tumor suppressor pathway activation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Causes and consequences of centrosome abnormalities in cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

The centrosome-Golgi apparatus nexus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

The centriole duplication cycle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

The centrosome duplication cycle in health and disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Oncogene-like induction of cellular invasion from centrosome amplification

6 July 2018

1 reference

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Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Loss of centrioles causes chromosomal instability in vertebrate somatic cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Control of cortical microtubule organization and desmosome stability by centrosomal proteins

6 July 2018

1 reference

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p53 N-terminal phosphorylation: a defining layer of complex regulation

6 July 2018

1 reference

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Deconstructing the centriole: structure and number control

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Cilia functions in development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Comprehensive analysis of kinase inhibitor selectivity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Pharmacologic activation of p53 by small-molecule MDM2 antagonists

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Axon extension occurs independently of centrosomal microtubule nucleation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

A mechanism linking extra centrosomes to chromosomal instability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

The mammalian centrosome and its functional significance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Plk4-induced centriole biogenesis in human cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Generation of noncentrosomal microtubule arrays

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

6 July 2018

Flies without centrioles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

SAK/PLK4 is required for centriole duplication and flagella development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

The Polo kinase Plk4 functions in centriole duplication

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

Regulation of p53 in response to DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4764081

RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1

6 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3 '[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

21 January 2018

1 reference

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Overview of the CCP4 suite and current developments

21 January 2018

1 reference

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Phasercrystallographic software

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

Genome engineering using the CRISPR-Cas9 system

21 January 2018

1 reference

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Functional dissection of mitotic regulators through gene targeting in human somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation

21 January 2018

1 reference

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Deuterosome-mediated centriole biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

Polo-like kinases: structural variations lead to multiple functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

Kinase-targeted libraries: the design and synthesis of novel, potent, and selective kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

Selectivity-determining residues in Plk1

21 January 2018

1 reference

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Dynamics of DNA replication factories in living cells

21 January 2018

1 reference

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21 January 2018

1 reference

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5111

Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli

21 January 2018

1 reference

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Linking Crystallographic Model and Data Quality

21 January 2018

1 reference

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The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5 '-methoxyspiro[cyclopropane-1,3 '-indolin]-2 '-one (CFI-400945) as a potent, orally active antitu

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25931445

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.AAA5111

1 reference

2 August 2017

1 reference

2 August 2017

1 reference