Synergistic targeted therapy for acute promyelocytic leukaemia: a model of translational research in human cancer. (Q38522309)

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16 February 2020

review article

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title

Synergistic targeted therapy for acute promyelocytic leukaemia: a model of translational research in human cancer (English)

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16 February 2020

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3

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16 February 2020

Guangbiao Zhou

4

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16 February 2020

author name string

J-Q Mi

1

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16 February 2020

S-J Chen

2

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16 February 2020

X-J Yan

5

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16 February 2020

Z Chen

6

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16 February 2020

language of work or name

English

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publication date

9 June 2015

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Journal of Internal Medicine

16 February 2020

published in

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16 February 2020

volume

278

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16 February 2020

issue

6

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16 February 2020

page(s)

627-642

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Acute Promyelocytc Leukemia

16 February 2020

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21 January 2018

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PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia

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PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.

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PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells

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Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

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Coordinated regulation of the immunoproteasome subunits by PML/RARα and PU.1 in acute promyelocytic leukemia

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Acute promyelocytic leukaemia: novel insights into the mechanisms of cure

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PML targeting eradicates quiescent leukaemia-initiating cells

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Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

21 January 2018

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Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

21 January 2018

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PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

21 January 2018

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PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia

21 January 2018

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Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide

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21 January 2018

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Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia

21 January 2018

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Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide

21 January 2018

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Arsenic trioxide therapy in relapsed or refractory Japanese patients with acute promyelocytic leukemia: updated outcomes of the phase II study and postremission therapies

21 January 2018

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21 January 2018

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Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia

21 January 2018

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Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia

21 January 2018

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Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.

21 January 2018

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PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3.

21 January 2018

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Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

21 January 2018

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RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

21 January 2018

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The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA

21 January 2018

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Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation

21 January 2018

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Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment

21 January 2018

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Triple A therapy: the molecular underpinnings of the unique sensitivity of leukemic promyelocytes to anthracyclines, all-trans-retinoic acid and arsenic trioxide

21 January 2018

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Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations

21 January 2018

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Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents

21 January 2018

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Targeted therapy: The new lease on life for acute promyelocytic leukemia, and beyond.

21 January 2018

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Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia

21 January 2018

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All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia

21 January 2018

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Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia

21 January 2018

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Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukemia cells

21 January 2018

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Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation

21 January 2018

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Retinoid/arsenic combination therapy of promyelocytic leukemia: induction of telomerase-dependent cell death

21 January 2018

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Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission

21 January 2018

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Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation

21 January 2018

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Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

21 January 2018

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Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo

21 January 2018

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Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia

21 January 2018

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Effective treatment of acute promyelocytic leukemia with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin

21 January 2018

1 reference

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Single cycle of arsenic trioxide-based consolidation chemotherapy spares anthracycline exposure in the primary management of acute promyelocytic leukemia

21 January 2018

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Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710.

21 January 2018

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Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

21 January 2018

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Oral tetra-arsenic tetra-sulfide formula versus intravenous arsenic trioxide as first-line treatment of acute promyelocytic leukemia: a multicenter randomized controlled trial.

21 January 2018

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Arsenic trioxide during consolidation for patients with previously untreated low/intermediate risk acute promyelocytic leukaemia may eliminate the need for maintenance therapy

21 January 2018

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Mutations of Epigenetic Modifier Genes as a Poor Prognostic Factor in Acute Promyelocytic Leukemia Under Treatment With All-Trans Retinoic Acid and Arsenic Trioxide

21 January 2018

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8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JOIM.12376

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26058416%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26058416%20AND%20SRC:MED&resulttype=core&format=json