H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells (Q38515287)

3 September 2017

H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells (English)

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3 September 2017

4

Hyeong-Reh Choi Kim

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3 September 2017

5

Aree Moon

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3 September 2017

Ilchung Shin

1

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3 September 2017

Seonhoe Kim

series ordinal

2

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3 September 2017

Hyun Song

series ordinal

3

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3 September 2017

language of work or name

English

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publication date

27 January 2005

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Journal of Biological Chemistry

3 September 2017

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3 September 2017

280

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3 September 2017

15

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3 September 2017

14675-14683

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Understanding Ras: 'it ain't over 'til it's over'.

3 September 2017

1 reference

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Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells: involvement of Rac and MAP kinase activity

21 January 2018

1 reference

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Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis

21 January 2018

1 reference

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Function and regulation of ras.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411625200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Proteins regulating Ras and its relatives

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411625200

Signal transduction. How receptors turn Ras on.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411625200

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Differential activation of the Rac pathway by Ha-Ras and K-Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Raf-1 activates MAP kinase-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

An essential role for Rac in Ras transformation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411625200

Phosphatidylinositol 3-kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411625200

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

21 January 2018

1 reference

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Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

21 January 2018

1 reference

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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38

21 January 2018

1 reference

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Signaling pathways for PC12 cell differentiation: making the right connections

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Ras effectors and their role in mitogenesis and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Increasing complexity of Ras signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Akt signaling: linking membrane events to life and death decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

PI3K: downstream AKTion blocks apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Targeting RAS signalling pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Rho GTPases in cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Identification of stathmin as a novel substrate for p38 delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

The oncoprotein 18/stathmin family of microtubule destabilizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Paxillin: a focal adhesion-associated adaptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Phosphoinositide 3-kinase-dependent activation of Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Phosphorylation and regulation of Raf by Akt (protein kinase B)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Regulation of Raf-Akt Cross-talk

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

The PI 3-kinase-Rac-p38 MAP kinase pathway is involved in the formation of signet-ring cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes

21 January 2018

1 reference

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Ras signalling on the endoplasmic reticulum and the Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization

21 January 2018

1 reference

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Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential

21 January 2018

1 reference

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ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1: Involvement of the ras dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

Mutation of Ha-Ras C Terminus Changes Effector Pathway Utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411625200

21 January 2018

Identifiers

DOI

10.1074/JBC.M411625200

1 reference

3 September 2017

1 reference