Paxillin: a focal adhesion-associated adaptor protein (Q30167845)

9 June 2017

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title

Paxillin: a focal adhesion-associated adaptor protein (English)

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9 June 2017

Schaller MD

1

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PubMed ID

11607845

9 June 2017

language of work or name

English

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publication date

1 October 2001

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9 June 2017

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9 June 2017

20

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9 June 2017

6459-6472

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9 June 2017

44

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Differential effects of platelet-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbit aortic vascular smooth muscle cells and Swiss 3T3 fibroblasts

9 June 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Identification of a new Pyk2 target protein with Arf-GAP activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

RAFTK/Pyk2-mediated cellular signalling

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Rapid impact of beta-amyloid on paxillin in a neural cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Paxillin LD motifs may define a new family of protein recognition domains

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Focal adhesions, contractility, and signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

The role of ARF and Rab GTPases in membrane transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Paxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Identification of a second transforming function in bovine papillomavirus type 1 E6 and the role of E6 interactions with paxillin, E6BP, and E6AP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

LIM domains: multiple roles as adapters and functional modifiers in protein interactions

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Integrin alpha v beta 5-dependent serine phosphorylation of paxillin in cultured human macrophages adherent to vitronectin.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Cell-substrate interactions and signaling through ILK

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Regulators and effectors of the ARF GTPases.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Physiological signals and oncogenesis mediated through Crk family adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Control of adhesion-dependent cell survival by focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Cloning and characterization of Dfak56, a homolog of focal adhesion kinase, in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Beta 2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Complement receptor 3 (CR3, Mac-1, integrin alpha M beta 2, CD11b/CD18) is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

The Csk homologous kinase, Chk, binds tyrosine phosphorylated paxillin in human blastic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Angiotensin II induces migration and Pyk2/paxillin phosphorylation of human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Src family kinases are required for integrin but not PDGFR signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Integrins regulate the association and phosphorylation of paxillin by c-Abl

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Leupaxin is a novel LIM domain protein that forms a complex with PYK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Paxillin binding to a conserved sequence motif in the alpha 4 integrin cytoplasmic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Paxillin isoforms in mouse. Lack of the gamma isoform and developmentally specific beta isoform expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

The LIM domains of hic-5 protein recognize specific DNA fragments in a zinc-dependent manner in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3- or anti-CD45-stimulated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

DFak56 is a novel Drosophila melanogaster focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Protein tyrosine phosphatase phi regulates paxillin tyrosine phosphorylation and mediates colony-stimulating factor 1-induced morphological changes in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Differential signaling by the focal adhesion kinase and cell adhesion kinase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Signaling through focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

SH2 domains recognize specific phosphopeptide sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Adenovirus-mediated overexpression of C-terminal Src kinase (Csk) in type I astrocytes interferes with cell spreading and attachment to fibronectin. Correlation with tyrosine phosphorylations of paxillin and FAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Specific and redundant roles of Src and Fyn in organizing the cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Paxillin: a new vinculin-binding protein present in focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

The cloning, genomic organization and expression of the focal contact protein paxillin in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Lipopolysaccharide induces actin reorganization and tyrosine phosphorylation of Pyk2 and paxillin in monocytes and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

7 January 2021

Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

7 January 2021

Respiratory infections. An opportunity for integrated disease management

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

7 January 2021

Specific decrease in the level of Hic-5, a focal adhesion protein, during immortalization of mouse embryonic fibroblasts, and its association with focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

7 January 2021

Nerve growth factor stimulates tyrosine phosphorylation of paxillin in PC12h cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

7 January 2021

Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

7 January 2021

Angiotensin II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

7 January 2021

Hypoxia induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

7 January 2021

Mechanosensitive tyrosine phosphorylation of paxillin and focal adhesion kinase in tracheal smooth muscle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

7 January 2021

The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

7 January 2021

Serine phosphorylation of paxillin by heregulin-beta1: role of p38 mitogen activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204786

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204786

1 reference

PubMed ID

11607845

Dimensions Publication ID

9 June 2017

0 references

1 reference

PubMed ID

11607845