Chemical biology of anticancer gold(III) and gold(I) complexes (Q38418786)

2 September 2017

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title

Chemical biology of anticancer gold(III) and gold(I) complexes (English)

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2 September 2017

5

Chi-Ming Che

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2 September 2017

Taotao Zou

1

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2 September 2017

Ching Tung Lum

series ordinal

2

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2 September 2017

Chun-Nam Lok

series ordinal

3

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2 September 2017

Jing-Jing Zhang

series ordinal

4

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2 September 2017

14 April 2015

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2 September 2017

Chemical Society Reviews

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2 September 2017

44

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2 September 2017

24

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2 September 2017

8786-8801

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The chemistry of gold drugs

2 September 2017

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https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold-based therapeutic agents

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5CS00132C

Therapeutic applications of gold complexes: lipophilic gold(III) cations and gold(I) complexes for anti-cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Next-generation metal anticancer complexes: multitargeting via redox modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(III) complexes as potential antitumor agents: solution chemistry and cytotoxic properties of some selected gold(III) compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Towards the rational design of platinum(II) and gold(III) complexes as antitumour agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Antitumor properties of some 2-[(dimethylamino)methyl]phenylgold(III) complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Solution chemistry and cytotoxic properties of novel organogold(III) compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Phosphine-gold(I) compounds as anticancer agents: general description and mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

N-Heterocyclic carbene metal complexes in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Antitumor activity of diethynylfluorene derivatives of gold(I).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

On the biological properties of alkynyl phosphine gold(I) complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(I) complex of N,N'-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition of thioredoxin reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Glutathione homeostasis and functions: potential targets for medical interventions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold compounds as therapeutic agents for human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Cysteine cathepsins: multifunctional enzymes in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Thioredoxin reductase as a novel molecular target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Thioredoxin system in cell death progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Cysteine proteases as targets for metal-based drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A synthetic model for the inhibition of glutathione peroxidase by antiarthritic gold compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Targeting aquaporin function: potent inhibition of aquaglyceroporin-3 by a gold-based compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Aquaporin inhibition by gold(III) compounds: new insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Deubiquitinases as potential anti-cancer targets for gold(III) complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

The mode of action of anticancer gold-based drugs: a structural perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Stable anticancer gold(III)-porphyrin complexes: effects of porphyrin structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(III) porphyrin complex is more potent than cisplatin in inhibiting growth of nasopharyngeal carcinoma in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold (III) porphyrin complexes induce apoptosis and cell cycle arrest and inhibit tumor growth in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Inhibition of Akt sensitises neuroblastoma cells to gold(III) porphyrin 1a, a novel antitumour drug induced apoptosis and growth inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A gold(III) porphyrin complex as an anti-cancer candidate to inhibit growth of cancer-stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A gold(III) porphyrin complex with antitumor properties targets the Wnt/beta-catenin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A cytotoxic and cytostatic gold(III) corrole

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Anticancer cyclometalated [Au(III)m(C(wedge)N(wedge)C)mL]n+ compounds: Synthesis and cytotoxic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Metal compounds for the treatment of parasitic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Proteomic analysis of A2780/S ovarian cancer cell response to the cytotoxic organogold(III) compound Aubipy(c).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Synthesis of apoptosis-inducing iminophosphorane organogold(III) complexes and study of their interactions with biomolecular targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Iminophosphorane-organogold(III) complexes induce cell death through mitochondrial ROS production

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A dual cytotoxic and anti-angiogenic water-soluble gold(III) complex induces endoplasmic reticulum damage in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(III) complexes containing N-heterocyclic carbene ligands: thiol "switch-on" fluorescent probes and anti-cancer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(III) macrocycles: nucleotide-specific unconventional catalytic inhibitors of human topoisomerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(III)-dithiocarbamato complexes induce cancer cell death triggered by thioredoxin redox system inhibition and activation of ERK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Latest insights into the anticancer activity of gold(III)-dithiocarbamato complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Carbene complexes of gold: preparation, medical application and bonding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

The medicinal applications of imidazolium carbene-metal complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Beyond catalysis: N-heterocyclic carbene complexes as components for medicinal, luminescent, and functional materials applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Advances in metal-carbene complexes as potent anti-cancer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Metal/N-heterocyclic carbene complexes: opportunities for the development of anticancer metallodrugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

N-Heterocyclic carbene metal complexes: photoluminescence and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

The role of p38 MAPK activation in auranofin-induced apoptosis of human promyelocytic leukaemia HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(I) chloride adducts of 1,3-bis(di-2-pyridylphosphino)propane: synthesis, structural studies and antitumour activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

In vitro and in vivo antitumor properties of tetrakis((trishydroxy- methyl)phosphine)gold(I) chloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Anticancer gold(I)-phosphine complexes as potent autophagy-inducing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Cationic, linear Au(I) N-heterocyclic carbene complexes: synthesis, structure and anti-mitochondrial activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Cytotoxic gold(I) N-heterocyclic carbene complexes with phosphane ligands as potent enzyme inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A binuclear gold(I) complex with mixed bridging diphosphine and bis(N-heterocyclic carbene) ligands shows favorable thiol reactivity and inhibits tumor growth and angiogenesis in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Encapsulation of dual cytotoxic and anti-angiogenic gold(III) complexes by gelatin-acacia microcapsules: in vitro and in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Organogold(III) supramolecular polymers for anticancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Thioredoxin reductase, an emerging target for anticancer metallodrugs. Enzyme inhibition by cytotoxic gold(iii) compounds studied with combined mass spectrometry and biochemical assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Gold(iii) complexes inhibit growth of cisplatin-resistant ovarian cancer in association with upregulation of proapoptotic PMS2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

A dinuclear cyclometalated gold(iii)–phosphine complex targeting thioredoxin reductase inhibits hepatocellular carcinoma in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

Bioinorganic and medicinal chemistry: aspects of gold(i)-protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5CS00132C

21 January 2018

Identifiers

DOI

10.1039/C5CS00132C

1 reference

2 September 2017

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