STAT3 the oncogene - still eluding therapy? (Q38396909)

2 September 2017

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title

STAT3 the oncogene - still eluding therapy? (English)

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2 September 2017

Matthew S Wake

1

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PubMed ID

25825152

2 September 2017

Christine J Watson

series ordinal

2

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PubMed ID

25825152

2 September 2017

language of work or name

English

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publication date

22 April 2015

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2 September 2017

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2 September 2017

282

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2 September 2017

14

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2 September 2017

2600-2611

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Assignment of the acute phase response factor (APRF) gene to 17q21 by microdissection clone sequencing and fluorescence in situ hybridization of a P1 clone

2 September 2017

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https://api.crossref.org/works/10.1111%2FFEBS.13285

The STAT3 isoforms alpha and beta have unique and specific functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Crystal structure of unphosphorylated STAT3 core fragment

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Activation and association of Stat3 with Src in v-Src-transformed cell lines

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

A family of cytokine-inducible inhibitors of signalling

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Specific inhibition of Stat3 signal transduction by PIAS3

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Protein tyrosine phosphatases in the JAK/STAT pathway

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Stat3 activation is required for cellular transformation by v-src

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Stat3 regulates genes common to both wound healing and cancer

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13285

Knockdown of Stat3 expression using RNAi inhibits growth of laryngeal tumors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Low PIAS3 expression in malignant mesothelioma is associated with increased STAT3 activation and poor patient survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Inhibition of the JAK/STAT pathway with ruxolitinib overcomes cisplatin resistance in non-small-cell lung cancer NSCLC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

A high-throughput fluorescence polarization assay for signal transducer and activator of transcription 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Fragment-based drug design and drug repositioning using multiple ligand simultaneous docking (MLSD): identifying celecoxib and template compounds as novel inhibitors of signal transducer and activator of transcription 3 (STAT3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Binding modes of peptidomimetics designed to inhibit STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Real time analysis of STAT3 nucleocytoplasmic shuttling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Therapeutic modulators of STAT signalling for human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Peptides as therapeutics with enhanced bioactivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Is there a future for cell-penetrating peptides in oligonucleotide delivery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13285

21 January 2018

Identifiers

DOI

10.1111/FEBS.13285

1 reference

2 September 2017

1 reference

PubMed ID

25825152