The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development. (Q38341764)

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9 February 2020

title

The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development (English)

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9 February 2020

1

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9 February 2020

Klaus Okkenhaug

7

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5

Bart Vanhaesebroeck

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9 February 2020

author name string

Daniel J Bolland

2

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9 February 2020

Fabien Garcon

3

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9 February 2020

Juliet L Emery

4

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9 February 2020

Anne E Corcoran

6

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9 February 2020

publication date

10 August 2010

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9 February 2020

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9 February 2020

volume

3

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9 February 2020

page(s)

ra60

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9 February 2020

issue

134

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Fine tuning the immune response with PI3K.

9 February 2020

cites work

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6 September 2017

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The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.

6 September 2017

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The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

6 September 2017

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Signalling through Class I PI3Ks in mammalian cells

6 September 2017

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Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

6 September 2017

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Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus

6 September 2017

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Basal immunoglobulin signaling actively maintains developmental stage in immature B cells

6 September 2017

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Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase

6 September 2017

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Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

6 September 2017

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Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

6 September 2017

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A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

6 September 2017

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Synthesis and function of 3-phosphorylated inositol lipids

6 September 2017

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B cell development pathways

6 September 2017

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Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Requirement for B cell linker protein (BLNK) in B cell development

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool

6 September 2017

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Cell cycle regulation of V(D)J recombination-activating protein RAG-2.

6 September 2017

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RAG-1-deficient mice have no mature B and T lymphocytes

6 September 2017

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

6 September 2017

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Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4.

6 September 2017

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Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells

14 September 2017

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The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis

27 September 2017

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Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement

27 September 2017

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Involvement of the c-kit receptor in the adhesion of hematopoietic stem cells to stromal cells.

27 September 2017

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PI3 kinase signals BCR-dependent mature B cell survival

27 September 2017

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The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Transcription of productive and nonproductive VDJ-recombined alleles after IgH allelic exclusion

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540743

The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells

31 August 2018

1 reference

12 December 2020

Transgenic mice with hematopoietic and lymphoid specific expression of Cre

1 reference

12 December 2020

The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation

1 reference

12 December 2020

Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression

1 reference

12 December 2020

The PI3K p110delta is required for down-regulation of RAG expression in immature B cells

1 reference

12 December 2020

10.1126/SCISIGNAL.2001104

Identifiers

DOI

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9 February 2020

1 reference

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9 February 2020

1 reference