Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase (Q24313357)

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5 January 2020

title

Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase (English)

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7

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author name string

Kyung D Moon

1

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5 January 2020

Carol B Post

2

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5 January 2020

Donald L Durden

3

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5 January 2020

Qing Zhou

4

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5 January 2020

Pradip De

5

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5 January 2020

Marietta L Harrison

6

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publication date

9 November 2004

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Journal of Biological Chemistry

5 January 2020

language of work or name

English

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published in

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volume

280

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5 January 2020

issue

2

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5 January 2020

page(s)

1543-1551

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Tyrosine kinase SYK: essential functions for immunoreceptor signalling

5 January 2020

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Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323

21 January 2018

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Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk

21 January 2018

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Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

21 January 2018

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Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr

21 January 2018

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Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase

21 January 2018

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Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells

21 January 2018

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SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling

21 January 2018

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A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages

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Regulation of Akt-dependent cell survival by Syk and Rac.

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Syk regulation of phosphoinositide 3-kinase-dependent NK cell function

21 January 2018

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Syk is required for the activation of Akt survival pathway in B cells exposed to oxidative stress

21 January 2018

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B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase

21 January 2018

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TEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways

21 January 2018

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BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation

21 January 2018

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The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor.

21 January 2018

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Signal transduction by human-restricted Fc gamma RIIa involves three distinct cytoplasmic kinase families leading to phagocytosis

21 January 2018

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Phosphoinositide 3-Kinase and p72 Noncovalently Associate with the Low Affinity Fc Receptor on Human Platelets through an Immunoreceptor Tyrosine-based Activation Motif

21 January 2018

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Translocation, activation and association of protein-tyrosine kinase (p72syk) with phosphatidylinositol 3-kinase are early events during platelet activation

21 January 2018

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SH2 domains recognize specific phosphopeptide sequences

21 January 2018

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Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

21 January 2018

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Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine

21 January 2018

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Treatment of T cells with 2-hydroxymyristic acid inhibits the myristoylation and alters the stability of p56lck

21 January 2018

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PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac.

21 January 2018

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Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation

21 January 2018

1 reference

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Human spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/56Lyn and a 120-kDa phosphoprotein

21 January 2018

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CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk

21 January 2018

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Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement

21 January 2018

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7 January 2021

Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration

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Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk

21 January 2018

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Diversity in the SH2 domain family phosphotyrosyl peptide binding site

21 January 2018

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A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor

21 January 2018

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Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt

21 January 2018

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The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.

21 January 2018

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Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells.

21 January 2018

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Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.

21 January 2018

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Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases

21 January 2018

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The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

21 January 2018

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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

21 January 2018

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Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach

21 January 2018

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Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

21 January 2018

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Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12).

21 January 2018

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YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase

21 January 2018

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Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

21 January 2018

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Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides

21 January 2018

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7 January 2021

Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck

1 reference

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7 January 2021

Point mutation of a tyrosine in the linker region of Syk results in a gain of function

1 reference

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7 January 2021

Identifiers

DOI

10.1074/JBC.M407805200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15536084%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference