Novel NF-κB inhibitors: a patent review (2011 - 2014). (Q38305549)

2 September 2017

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title

Novel NF-κB inhibitors: a patent review (2011 - 2014). (English)

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2 September 2017

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Jae-Kyung Jung

3

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author name string

Sateesh Kumar Arepalli

series ordinal

1

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2 September 2017

Minho Choi

series ordinal

2

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2 September 2017

Heesoon Lee

series ordinal

4

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2 September 2017

language of work or name

English

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publication date

2 January 2015

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Expert Opinion on Therapeutic Patents

2 September 2017

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2 September 2017

25

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2 September 2017

3

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2 September 2017

319-334

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Multiple nuclear factors interact with the immunoglobulin enhancer sequences

2 September 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Rel/NF-kappa B and I kappa B proteins: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Nuclear factor-kappa B inhibitors; a patent review (2006-2010).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.998199

The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.998199

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

The essential role of MEKK3 in TNF-induced NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Regulatory functions of ubiquitination in the immune system

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Two pathways to NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Nuclear factor-kappaB: its role in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

The role of nuclear factor-kappa B in pulmonary diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Mechanical stretch activates nuclear factor-kappaB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: implications in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Activation and localization of transcription factor, nuclear factor-kappaB, in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

A small molecule inhibitor of redox-regulated NF-kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Hostile takeovers: viral appropriation of the NF-kB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

RNA interference directed against viral and cellular targets inhibits human immunodeficiency Virus Type 1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

A critical role for the NFkB pathway in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated by NFKB via PI3K/AKT signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

NF-kB and c-Jun induce the expression of the oncogenic miR-221 and miR-222 in prostate carcinoma and glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Receptor activator of NF-kB (RANK) expression in primary tumors associates with bone metastasis occurrence in breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

The prognostic impact of TGF-β1, fascin, NF-κB and PKC-ζ expression in soft tissue sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Requirement for NF-kappaB in osteoclast and B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Activation of NF-kappaB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Cell specific effects of glucocorticoid treatment on the NF-kappaBp65/IkappaBalpha system in patients with Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Limb and skin abnormalities in mice lacking IKKalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Role of cysteine residues of p65/NF-kappaB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Inhibitors of NF-kappaB signaling: 785 and counting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription. Requirement for an additional activation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Design and synthesis of 3,4-dihydro-2H-benzo[h]chromene derivatives as potential NF-κB inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Circuitry of nuclear factor kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

The dynamics of signaling as a pharmacological target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

Activation of nuclear factor kappa B in Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.998199

10.1517/13543776.2014.998199

21 January 2018

Identifiers

DOI

1 reference

2 September 2017

1 reference