Nuclear factor-kappa B inhibitors; a patent review (2006-2010). (Q37958061)

25 August 2017

Nuclear factor-kappa B inhibitors; a patent review (2006-2010). (English)

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25 August 2017

Jae-Hwan Kwak

1

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Jae-Kyung Jung

object named as

Jae-Kyung Jung

series ordinal

2

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author name string

Heesoon Lee

series ordinal

3

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PubMed ID

22098320

25 August 2017

language of work or name

English

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publication date

1 December 2011

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Expert Opinion on Therapeutic Patents

25 August 2017

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25 August 2017

21

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25 August 2017

12

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25 August 2017

1897-1910

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Multiple nuclear factors interact with the immunoglobulin enhancer sequences

25 August 2017

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https://api.crossref.org/works/10.1517%2F13543776.2011.638285

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Nuclear factor-kappaB: its role in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Structure, regulation and function of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

An exceptionally well-preserved theropod dinosaur from the Yixian Formation of China

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Signal transduction through NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

NF-kappa B: ten years after

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Transcription factor NF-kappaB: a sensor for smoke and stress signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

NF-kappaB: a multifaceted transcription factor regulated at several levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Two pathways to NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

The generation of nfkb2 p52: mechanism and efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

WIP1 phosphatase is a negative regulator of NF-kappaB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Signals from within: the DNA-damage-induced NF-kappaB response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

NF-kappaB and the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Inflammatory bowel disease (1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Inflammatory bowel disease (2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Inverse regulation of the nuclear factor-kappaB binding to the p53 and interleukin-8 kappaB response elements in lesional psoriatic skin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

NF-κB as a potential therapeutic target in myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Nuclear factor-kappaB in cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Inhibition of inducible NF-kappaB activity reduces chemoresistance to 5-fluorouracil in human stomach cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Bcl-2 family proteins as targets for anticancer drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

p65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Signalling to drug resistance in CLL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Nuclear factor-kappa B and cancer: its role in prevention and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Antiproliferative effects of IFN-alpha correlate with the downregulation of nuclear factor-kappa B in human Burkitt lymphoma Daudi cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Nuclear transcription factor-kappaB in Hodgkin's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

New insights into the role of nuclear factor-kB in cell growth regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Simvastatin inhibits NF-kappaB signaling in intestinal epithelial cells and ameliorates acute murine colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Antiinflammatory and immunomodulating properties of fungal metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Beta-(1-->3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

PR-39, a proline-rich peptide antibiotic from pig, and FALL-39, a tentative human counterpart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Synthesis and structure-activity relationship of dehydroxymethylepoxyquinomicin analogues as inhibitors of NF-kappaB functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Inhibition of tumor necrosis factor-alpha -induced nuclear translocation and activation of NF-kappa B by dehydroxymethylepoxyquinomicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Inhibitory mechanism of chroman compound on LPS-induced nitric oxide production and nuclear factor-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Estrogen-induced creatine kinase in the reproductive system of the immature female rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

IL-8 and p53 are inversely regulated through JNK, p38 and NF-kappaB p65 in HepG2 cells during an inflammatory response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Patented inhibitors (2002 - 2005) of the transcription factor NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Strategies toward the design of novel and selective protein tyrosine kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.638285

10.1517/13543776.2011.638285

21 January 2018

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

22098320