Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges (Q38268345)

1 September 2017

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title

Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges (English)

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1 September 2017

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Joseph McInnes

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Klaudia Brix

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Klaudia Brix

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author name string

Alaa Al-Hashimi

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1 September 2017

Maren Rehders

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1 September 2017

Tripti Tamhane

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1 September 2017

Mads H Haugen

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1 September 2017

16 November 2014

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1 September 2017

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1 September 2017

252

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1 September 2017

755-774

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1 September 2017

3

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https://scigraph.springernature.com/pub.10.1007/s00709-014-0730-0

1 September 2017

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cites work

Splice variants of human cathepsin L mRNA show different expression rates

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Lysosomal cell death at a glance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Nucleoplasmic calcium regulates cell proliferation through legumain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Regulated secretion of conventional lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Identification and characterization of a novel human cathepsin L splice variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Regulated cell death: signaling and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Dual regulation of the LDL receptor--some clarity and new questions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteomic techniques and activity-based probes for the system-wide study of proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Regulation of human cathepsin B by alternative mRNA splicing: homeostasis, fatal errors and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Prediction of protease substrates using sequence and structure features

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cysteine proteases as disease markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Identification of two new exons and multiple transcription start points in the 5'-untranslated region of the human cathepsin-B-encoding gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The C-terminal subunit of artificially truncated human cathepsin B mediates its nuclear targeting and contributes to cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

ALIX and the multivesicular endosome: ALIX in Wonderland

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cystatin E/M suppresses legumain activity and invasion of human melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Lysosomal sorting receptors are essential for secretory granule biogenesis in Tetrahymena

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cysteine cathepsins: cellular roadmap to different functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cathepsin K inhibitors for osteoporosis and potential off-target effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Untangling structure-function relationships in the rhomboid family of intramembrane proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Inhibition of cathepsin L-like proteases by cathepsin V propeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Stefin B interacts with histones and cathepsin L in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cathepsins as transcriptional activators?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Emerging roles for cysteine proteases in human biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cloning and expression of mouse legumain, a lysosomal endopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Oxidative stress and "senescent" fibroblasts in non-healing wounds as potential therapeutic targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

A shortcut to the lysosome: the mannose-6-phosphate-independent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

21 January 2018

The lysosome turns fifty

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

New approaches for dissecting protease functions to improve probe development and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Protease proteomics: revealing protease in vivo functions using systems biology approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cysteine cathepsins and their potential in clinical therapy and biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Thyroid functions of mouse cathepsins B, K, and L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

A la carte proteomics with an emphasis on gel-free techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cysteine cathepsins and the cutting edge of cancer invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Characterization of the cathepsin B gene and multiple mRNAs in human tissues: evidence for alternative splicing of cathepsin B pre-mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Combating apoptosis and multidrug resistant cancers by targeting lysosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Therapeutic utility and medicinal chemistry of cathepsin C inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Redox regulation of cysteine-dependent enzymes in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Nuclear legumain activity in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Synthetic inhibitors of thrombin and factor Xa: from bench to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Inhibitors for the immuno- and constitutive proteasome: current and future trends in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Membrane fusion and exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5'-untranslated region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteins with neomorphic moonlighting functions in disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Multiple roles for cysteine cathepsins in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Structure-based development of specific inhibitors for individual cathepsins and their medical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The biogenesis of lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Antiprotease therapy in cancer: hot or not?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

TopFIND, a knowledgebase linking protein termini with function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

An overview of the serpin superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Target deconvolution techniques in modern phenotypic profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Protease activity: meeting its theranostic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Thyroid stimulating hormone upregulates secretion of cathepsin B from thyroid epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Toward computer-based cleavage site prediction of cysteine endopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteases: multifunctional enzymes in life and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

21 January 2018

The hallmarks of aging

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The biogenesis of lysosomes and lysosome-related organelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Biosynthesis of lysosomal proteinases in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Modes of acrosin functioning during fertilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteolytic networks in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The lysosomal cysteine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

In vivo expression of an alternatively spliced human tumor message that encodes a truncated form of cathepsin B. Subcellular distribution of the truncated enzyme in COS cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Autophagy: Molecular mechanisms and their implications for anticancer therapies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Selective targeting of tumor and stromal cells by a nanocarrier system displaying lipidated cathepsin B inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Post-transcriptional regulation of human cathepsin L expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cysteine cathepsins: multifunctional enzymes in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

21 January 2018

12 December 2020

The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The molecular machinery for lysosome biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Function of the two mannose 6-phosphate receptors in lysosomal enzyme transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Exon skipping of cathepsin B: mitochondrial targeting of a lysosomal peptidase provokes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Neuronal and microglial cathepsins in aging and age-related diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Brentuximab vedotin: a CD30-directed antibody-cytotoxic drug conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Activity-based protein profiling for biochemical pathway discovery in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cathepsin K: a unique collagenolytic cysteine peptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

DNA accelerates the inhibition of human cathepsin V by serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

In search of partners: linking extracellular proteases to substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Degradomics: systems biology of the protease web. Pleiotropic roles of MMPs in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cysteine cathepsin proteases as pharmacological targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The molecular switches controlling the interaction between complement proteases of the classical and lectin pathways and their substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Sphingolipid lysosomal storage disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Mannose 6-phosphate specific receptors: structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Human stefin B role in cell's response to misfolded proteins and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Caspase substrates and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Corruption of innate immunity by bacterial proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The 46-kDa mannose 6-phosphate receptor does not depend on endosomal acidification for delivery of hydrolases to lysosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Human and mouse proteases: a comparative genomic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Applications of small molecule probes in dissecting mechanisms of bacterial virulence and host responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Microenvironmental regulation of tumor progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Peptidase inhibitors in the MEROPS database

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

On the road to inflammation: linking lysosome disruption, lysosomal protease release and necrotic death of immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Specialized roles for cysteine cathepsins in health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Lysosomal-mitochondrial cross-talk during cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Lysosomes and lysosomal cathepsins in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Metabolic and cellular bases of sphingolipidoses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Selectivity of propeptide-enzyme interaction in cathepsin L-like cysteine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteome-wide analysis of protein carboxy termini: C terminomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The retromer complex - endosomal protein recycling and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteomic identification of protease cleavage sites: cell-biological and biomedical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Clostridium difficile toxins: mediators of inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Unicellular eukaryotes as models in cell and molecular biology: critical appraisal of their past and future value.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Applied techniques for mining natural proteasome inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

A human protein-protein interaction network: a resource for annotating the proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Sharpening rhomboid specificity by dimerisation and allostery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cell and environment interactions in tumor microregions: the multicell spheroid model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Human cathepsin B-encoding cDNAs: sequence variations in the 3'-untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Nuclear cysteine cathepsin variants in thyroid carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cathepsin B trafficking in thyroid carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Secretory granule biogenesis: rafting to the SNARE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Targeting proteases: successes, failures and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Special issue: Proteolysis 50 years after the discovery of lysosome in honor of Christian de Duve.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The cystatins: Protein inhibitors of cysteine proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Protease signalling in cell death: caspases versus cysteine cathepsins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Lysosomes as "suicide bags" in cell death: myth or reality?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cystatins: biochemical and structural properties, and medical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cysteine cathepsins: from structure, function and regulation to new frontiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Out with a bang! Tetrahymena as a model system to study secretory granule biogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

The rhomboid protease family: a decade of progress on function and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Intramembrane proteolysis controls diverse signalling pathways throughout evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Complementary positional proteomics for screening substrates of endo- and exoproteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Imaging and imagination: understanding the endo-lysosomal system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Intramembrane proteolysis by rhomboids: catalytic mechanisms and regulatory principles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Molecular recognition and targeting of lysosomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cystatin C properties crucial for uptake and inhibition of intracellular target enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Asparaginyl endopeptidase: case history of a class II MHC compartment protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Lysosomes integrate metabolic-inflammatory cross-talk in primary macrophage inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Functions of Propeptide Parts in Cysteine Proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Exploring the role of 5' alternative splicing and of the 3'-untranslated region of cathepsin B mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteases: Structure and Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Compartmentalization of Proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Thyroid Cathepsin K: Roles in Physiology and Thyroid Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Trafficking of lysosomal cathepsin B-green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

21 January 2018

12 December 2020

Emerging roles of proteases in tumour suppression

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Kinetics of the Interaction of Peptidases with Substrates and Modifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Differential expression of mRNAs for endopeptidases in phenotypically modulated (`dedifferentiated') human articular chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Proteases in Cancer: Significance for Invasion and Metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-014-0730-0

Subsite cooperativity in protease specificity

21 January 2018

1 reference

12 December 2020

Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin.

1 reference

12 December 2020

The interactomics of sortilin: an ancient lysosomal receptor evolving new functions

1 reference

12 December 2020

Use of fluorescent imaging to investigate pathological protease activity.

1 reference

12 December 2020

Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension

1 reference

12 December 2020

Cathepsins and their involvement in immune responses

1 reference

12 December 2020

Complete and limited proteolysis in cell cycle progression.

1 reference

12 December 2020

Intracellular signaling by cathepsin X: molecular mechanisms and diagnostic and therapeutic opportunities in cancer

1 reference

12 December 2020

Regulated secretion of mature cathepsin B from rat exocrine pancreatic cells

1 reference

12 December 2020

Legumain: asparaginyl endopeptidase

1 reference

12 December 2020

Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L.

1 reference

12 December 2020

Imaging of protease functions--current guide to spotting cysteine cathepsins in classical and novel scenes of action in mammalian epithelial cells and tissues

1 reference

12 December 2020

Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH

1 reference

12 December 2020

Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

1 reference

12 December 2020

Transcytosis in thyroid follicle cells: regulation and implications for thyroglobulin transport

1 reference

12 December 2020

Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy.

1 reference

12 December 2020

Identification of a rat liver alpha-N-acetylglucosaminyl phosphodiesterase capable of removing “blocking” alpha-N-acetylglucosamine residues from phosphorylated high mannose oligosaccharides of lysosomal enzymes

1 reference

12 December 2020

LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis

1 reference

12 December 2020

A role for stefin B (cystatin B) in inflammation and endotoxemia

1 reference

12 December 2020

Cathepsin B and its role(s) in cancer progression

1 reference

12 December 2020

Moonlighting vacuolar protease: multiple jobs for a busy protein

1 reference

12 December 2020

Molecular and computational analyses of genes involved in mannose 6-phosphate independent trafficking

1 reference

12 December 2020

Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells

1 reference

12 December 2020

Mechanism of interaction of cysteine proteinases and their protein inhibitors as compared to the serine proteinase-inhibitor interaction

1 reference

12 December 2020

MAME models for 4D live-cell imaging of tumor: microenvironment interactions that impact malignant progression

1 reference

12 December 2020

In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate

1 reference

12 December 2020

Cysteine proteinases mediate extracellular prohormone processing in the thyroid

1 reference

12 December 2020

Cathepsin B: multiple enzyme forms from a single gene and their relation to cancer

1 reference

12 December 2020

The two cysteine endopeptidases of legume seeds: purification and characterization by use of specific fluorometric assays

1 reference

12 December 2020

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity

1 reference

12 December 2020

Ready, set, cleave: proteases in action

1 reference

12 December 2020

Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site

1 reference

12 December 2020

Emerging roles of cysteine cathepsins in disease and their potential as drug targets.

1 reference

12 December 2020

10.1007/S00709-014-0730-0

Identifiers

DOI

1 reference

1 September 2017

1 reference